Expression of nanog gene promotes nih3t3 cell proliferation
文献类型：期刊论文
| 作者 | Zhang, JY; Wang, X; Chen, B; Suo, GL; Zhao, YH; Duan, ZY; Dai, JW |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2005-12-16 |
| 卷号 | 338期号:2页码:1098-1102 |
| 关键词 | Nanog Cell cycle Cell proliferation Nih3t3 |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2005.10.071 |
| 通讯作者 | Dai, jw() |
| 英文摘要 | Cells are the functional elements in tissue engineering and regenerative medicine. a large number of cells are usually needed for these purposes. however, there are numbers of limitations for in vitro cell proliferation. nanog is an important self-renewal determinant in embryonic stem cells. however, it remains unknown whether nanog will influence the cell cycle and cell proliferation of mature cells. in this study, we expressed nanog in nih3t3 cells and showed that expression of nanog in nih3t3 promoted cells to enter into s phase and enhanced cell proliferation. this suggests that nanog gene might function in a similar fashion in mature cells as in es cells. in addition, it may provide an approach for in vitro cell expansion. (c) 2005 elsevier inc. all rights reserved. |
| WOS关键词 | MAMMALIAN-CELLS ; STEM-CELLS ; S-PHASE ; PLURIPOTENCY ; PROTEIN ; GROWTH ; LINES ; CYCLE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000233451100056 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378053 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, JW |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, JY,Wang, X,Chen, B,et al. Expression of nanog gene promotes nih3t3 cell proliferation[J]. Biochemical and biophysical research communications,2005,338(2):1098-1102. |
| APA | Zhang, JY.,Wang, X.,Chen, B.,Suo, GL.,Zhao, YH.,...&Dai, JW.(2005).Expression of nanog gene promotes nih3t3 cell proliferation.Biochemical and biophysical research communications,338(2),1098-1102. |
| MLA | Zhang, JY,et al."Expression of nanog gene promotes nih3t3 cell proliferation".Biochemical and biophysical research communications 338.2(2005):1098-1102. |
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来源：中国科学院大学
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