Philinopside a, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects
文献类型：期刊论文
| 作者 | Tong, YG; Zhang, XW; Tian, F; Yi, YH; Xu, QZ; Li, L; Tong, LJ; Lin, LP; Ding, J |
| 刊名 | International journal of cancer
 |
| 出版日期 | 2005-05-10 |
| 卷号 | 114期号:6页码:843-853 |
| 关键词 | Philinopside a Receptor tyrosine kinase Tumor angiogenesis |
| ISSN号 | 0020-7136 |
| DOI | 10.1002/ijc.20804 |
| 通讯作者 | Ding, j(ding@mail.shcre.ac.cn) |
| 英文摘要 | Philinopside a is a novel sulfated saponin isolated from the sea cucumber, pentacta quadrangulari. the effects of philinopside a on angiogenesis and tumor growth were assessed in a series of models in vitro and in vivo. our results demonstrated that philinopside a significantly inhibited the proliferation, migration and tube formation of human microvascular endothelial cells (hmecs) in a dose-dependent manner, with average ic50 values of 1.4 +/- 0.17, 0.89 +/- 0.23 and 0.98 +/- 0.19 mu m, respectively. rat aortas culture assay provides a close imitation of in vivo angiogenesis process and 2-10 mu m philinopside a suppressed the formation of new microvessels in cultured rat aortas. philinopside a 2-10 nmol/egg obviously inhibited angiogenesis in chick embryo chorioallantoic membrane assay. in addition, philinopside a manifested strong anti-tumor activities both in vitro and in vivo. through immunofluorescent analysis, we found the compound reduced mouse sarcoma 180 tumor volume by inducing apoptosis of tumor and tumor-associated endothelial cells. an examination of the effects of philinopside a on the angiogenesis-related receptor tyrosine kinases (rtks) showed that philinopside a broadly inhibited all tested rtks, including vascular endothelial growth factor (vegf) receptor, fibroblast growth factor (fgf) receptor-1, platelet-derived growth factor (pdgf) receptor-beta and epithelial growth factor (egf) receptor, with ic50 values ranging from 2.6-4.9 mu m. these results suggest that philinopside a is a promising anti-cancer agent that possesses dual cytotoxic and anti-angiogenic effects that were at least partly due to its inhibitory effects on rtks. (c) 2005 wiley-liss, inc. |
| WOS关键词 | ENDOTHELIAL GROWTH-FACTOR ; RENAL-CELL CARCINOMA ; TYROSINE KINASE INHIBITORS ; IN-VITRO ANGIOGENESIS ; CHEMOTHERAPEUTIC-AGENTS ; TUMOR ANGIOGENESIS ; TUBE FORMATION ; PHASE-II ; RECEPTOR ; CANCER |
| WOS研究方向 | Oncology |
| WOS类目 | Oncology |
| 语种 | 英语 |
| WOS记录号 | WOS:000228338700001 |
| 出版者 | WILEY-BLACKWELL |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378083 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ding, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai Inst Mat Med, State Key Lab Drug Res,Div Anti Tumor Pharmacol, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Second Mil Med Univ, Sch Pharm, Res Ctr Marine Drugs, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tong, YG,Zhang, XW,Tian, F,et al. Philinopside a, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects[J]. International journal of cancer,2005,114(6):843-853. |
| APA | Tong, YG.,Zhang, XW.,Tian, F.,Yi, YH.,Xu, QZ.,...&Ding, J.(2005).Philinopside a, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects.International journal of cancer,114(6),843-853. |
| MLA | Tong, YG,et al."Philinopside a, a novel marine-derived compound possessing dual anti-angiogenic and anti-tumor effects".International journal of cancer 114.6(2005):843-853. |
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来源：中国科学院大学
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