Preparation, characterization and in vitro release of gentamicin from phbv/wollastonite composite microspheres
文献类型：期刊论文
| 作者 | Li, HY; Chang, J |
| 刊名 | Journal of controlled release
 |
| 出版日期 | 2005-10-20 |
| 卷号 | 107期号:3页码:463-473 |
| 关键词 | Phbv Wollastonite Microspheres Gentamicin Controlled release Apatite |
| ISSN号 | 0168-3659 |
| DOI | 10.1016/j.jconrel.2005.05.019 |
| 通讯作者 | Chang, j() |
| 英文摘要 | Composite microspheres have been prepared from bioactive wollastonite (w) and biodegradable poly (hydroxybutyrate-polyhydroxyvalerate) (phbv) in the present study. gentamicin was encapsulated into the microspheres by the absorption method and the in vitro release of the gentamicin from the microspheres was performed in distilled water, modified simulated body fluid (sbf) and phosphate buffered saline (pbs) at 37 degrees c for 22 days, respectively. the results showed that the release behavior of gentamicin from phbv/w composite microspheres was similar to that from the pure phbv microspheres when the experiment was performed in distilled water. however, in the pbs and sbf solutions, gentamicin released from the phbv/w composite microspheres at a relatively lower rate as compared to that of the pure phbv microspheres and 90% of the total amount of gentamicin released from the composite microspheres after soaking for 22 days, which was much longer than that for the release of the same amount gentamicin from the pure phbv microspheres (8 days). scanning electron microscopy (sem) and energy-dispersive spectrometer (eds) analysis on the microspheres after release in sbf and pbs revealed that a microporous apatite layer was formed on the composite microspheres surface, which resulted in a controlled release behavior of the gentamicin from the phbv/w composite microspheres. all of these results provided the possibility that the phbv/w composite microspheres could be applied as alternative drug controlled release systems, especially as bone fillings for bone repair due to their advantages of controlled releasing antibiotics and apatite-formation ability, through which the implanted microspheres could chemically bond to the surrounding tissue in vivo. (c) 2005 published by elsevier b.v. |
| WOS关键词 | DRUG-DELIVERY ; BONE-CEMENT ; TISSUE ; MICROPARTICLES ; BIOACTIVITY ; FABRICATION ; SCAFFOLDS ; MECHANISM ; KINETICS ; SULFATE |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| WOS类目 | Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000232746700007 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378098 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chang, J |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai 200050, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, HY,Chang, J. Preparation, characterization and in vitro release of gentamicin from phbv/wollastonite composite microspheres[J]. Journal of controlled release,2005,107(3):463-473. |
| APA | Li, HY,&Chang, J.(2005).Preparation, characterization and in vitro release of gentamicin from phbv/wollastonite composite microspheres.Journal of controlled release,107(3),463-473. |
| MLA | Li, HY,et al."Preparation, characterization and in vitro release of gentamicin from phbv/wollastonite composite microspheres".Journal of controlled release 107.3(2005):463-473. |
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来源：中国科学院大学
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