Application of rnai to cancer research and therapy
文献类型：期刊论文
| 作者 | Tan, FL; Yin, JQ |
| 刊名 | Frontiers in bioscience
 |
| 出版日期 | 2005-05-01 |
| 卷号 | 10页码:1946-u6 |
| 关键词 | Rnai Cancer Sirnas Mirnas Shrnas Review |
| ISSN号 | 1093-9946 |
| 通讯作者 | Yin, jq() |
| 英文摘要 | The introduction of double-stranded rna (dsrna) into cells can effectively and specifically lead to the degradation of corresponding mrnas in a gene-dependent manner, which is defined as rna interfering (rnai). this powerful technology has been widely employed to manipulate gene expression in mammalian and human cells, elucidate signal pathways and identify gene functions in a whole-genome scale. simultaneously, many pharmaceutical companies are very interested in the research and development of rnai-based drugs for various diseases, especially in cancers. in present review, we attempt to recapitulate the potential application of this breakthrough technology in many aspects of cancer gene therapy such as genome-scale screens, target identification and validation, functional analysis and animal models for diverse diseases. |
| WOS关键词 | SMALL INTERFERING RNAS ; HUMAN BREAST-CANCER ; FUNCTIONAL GENOMIC ANALYSIS ; CULTURED-MAMMALIAN-CELLS ; SHORT HAIRPIN RNAS ; HEPATITIS-B-VIRUS ; NF-KAPPA-B ; GENE-EXPRESSION ; C-ELEGANS ; IN-VIVO |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000232319800077 |
| 出版者 | FRONTIERS IN BIOSCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378115 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yin, JQ |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100864, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tan, FL,Yin, JQ. Application of rnai to cancer research and therapy[J]. Frontiers in bioscience,2005,10:1946-u6. |
| APA | Tan, FL,&Yin, JQ.(2005).Application of rnai to cancer research and therapy.Frontiers in bioscience,10,1946-u6. |
| MLA | Tan, FL,et al."Application of rnai to cancer research and therapy".Frontiers in bioscience 10(2005):1946-u6. |
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来源：中国科学院大学
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