Interaction of anticancer drug mitoxantrone with dna analyzed by electrochemical and spectroscopic methods
文献类型：期刊论文
| 作者 | Li, N; Ma, Y; Yang, C; Guo, LP; Yang, XR |
| 刊名 | Biophysical chemistry
 |
| 出版日期 | 2005-08-01 |
| 卷号 | 116期号:3页码:199-205 |
| 关键词 | Mitoxantrone Dna Interaction Electrochemistry Spectroscopic methods |
| ISSN号 | 0301-4622 |
| DOI | 10.1016/j.bpc.2005.04.009 |
| 通讯作者 | Yang, xr() |
| 英文摘要 | Cyclic voltammetry coupled with different spectroscopic (uv/vis), fluorescence and raman) techniques were used to study the interaction of mitoxantrone (mtx), an antitumor drug, with calf thymus dna in acetate buffer solutions (ph 4.5). the interaction of mtx with dna could result a considerable decrease in the mtx peak currents and a hypochromic and bathochromic shift in the maximum adsorption bands of mtx as well as the emission quenching in the mtx fluorescence spectra. the variations in the electrochemical and spectral characteristics of mtx indicated mtx bind to dna by an intercalative mode. this conclusion was reinforced by raman data. the merely particular vibrations were affected in raman, suggesting that only a portion of the chromophore of mtx was involved in the intercalation into dna duplex. these studies are valuable for a better understanding the detailed mode of mtx-dna interaction, which should be important in deeper insight into the therapeutic efficacy of mtx and design of new dna targeted drug. (c) 2005 elsevier b.v. all rights reserved. |
| WOS关键词 | NUCLEIC-ACIDS ; DEOXYRIBONUCLEIC ACIDS ; SEQUENCE SPECIFICITY ; AGENTS MITOXANTRONE ; ANTITUMOR DRUG ; AMETANTRONE ; DERIVATIVES ; DOXORUBICIN ; COMPLEXES ; BINDING |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000230717400004 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378133 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, XR |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.NE Normal Univ, Fac Chem, Changchun 130024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, N,Ma, Y,Yang, C,et al. Interaction of anticancer drug mitoxantrone with dna analyzed by electrochemical and spectroscopic methods[J]. Biophysical chemistry,2005,116(3):199-205. |
| APA | Li, N,Ma, Y,Yang, C,Guo, LP,&Yang, XR.(2005).Interaction of anticancer drug mitoxantrone with dna analyzed by electrochemical and spectroscopic methods.Biophysical chemistry,116(3),199-205. |
| MLA | Li, N,et al."Interaction of anticancer drug mitoxantrone with dna analyzed by electrochemical and spectroscopic methods".Biophysical chemistry 116.3(2005):199-205. |
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来源：中国科学院大学
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