Effects of atra on expression of mrna binding protein p62 in human gastric cancer cells
文献类型：期刊论文
| 作者 | Shi, P; Huang, ZW; Wang, SY; Zhang, JY; Peng, XX |
| 刊名 | Cell biology international
 |
| 出版日期 | 2005-02-01 |
| 卷号 | 29期号:2页码:127-131 |
| 关键词 | P62 Bgc-823 cells Confocal microscopy Electron microscopy All-trans-retinoic acid Insulin-like growth factor |
| ISSN号 | 1065-6995 |
| DOI | 10.1016/j.cellbi.2004.09.013 |
| 通讯作者 | Shi, p(ship723@yahoo.com) |
| 英文摘要 | The distribution of the cancer-associated protein p62 in human gastric carcinoma (bgc-823) cells was examined by confocal laser scanning microscopy and electron microscope immunocytochemistry. in control cells p62 was cytoplasmic in location and concentrated in the cytoplasmic matrix, but when cell growth was inhibited by treatment with 50 mu m all-trans-retinoic acid (atra) for 5 days, p62 expression decreased and the protein was translocated from cytoplasm to nucleus. ultrastructural localization using gold particles showed that p62 was bond mainly to a linear structure in nucleus. the speculation that p62 binds insulin-like growth factor (igf)-ii mrna indicates its probable involvement in the posttranscriptional igf-ii mrna processing and p62 could play a role in tumorgenesis by regulating the expression of igf-ii. further studies will be needed to confirm this view. (c) 2004 international federation for cell biology. published by elsevier ltd. all rights reserved. |
| WOS关键词 | II IGF-II ; GROWTH-FACTOR ; MAMMARY-CANCER ; WILMS TUMOR ; KH DOMAIN ; RETINOIDS ; MOTIF ; LOCALIZATION ; RECOGNITION ; RESPONSES |
| WOS研究方向 | Cell Biology |
| WOS类目 | Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000227997100004 |
| 出版者 | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378150 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Shi, P |
| 作者单位 | 1.Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China 2.E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Grad Sch, Shanghai 200032, Peoples R China 4.Univ Texas, El Paso, TX 79968 USA |
| 推荐引用方式 GB/T 7714 | Shi, P,Huang, ZW,Wang, SY,et al. Effects of atra on expression of mrna binding protein p62 in human gastric cancer cells[J]. Cell biology international,2005,29(2):127-131. |
| APA | Shi, P,Huang, ZW,Wang, SY,Zhang, JY,&Peng, XX.(2005).Effects of atra on expression of mrna binding protein p62 in human gastric cancer cells.Cell biology international,29(2),127-131. |
| MLA | Shi, P,et al."Effects of atra on expression of mrna binding protein p62 in human gastric cancer cells".Cell biology international 29.2(2005):127-131. |
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来源：中国科学院大学
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