Immune responses to six synthetic peptides of capsid protein with sera from hiv-1 infected individuals
文献类型：期刊论文
| 作者 | Liu, Guangjie1; Yang, Liumeng1; Wang, Jianhua1,2; Zhang, Gaohong1,2; Chen, Xiangmei1; Zheng, Yongtang1 |
| 刊名 | Cellular & molecular immunology
 |
| 出版日期 | 2005-08-01 |
| 卷号 | 2期号:4页码:289-293 |
| 关键词 | Hiv-1 Human serum Immune response P24 Synthetic peptide |
| ISSN号 | 1672-7681 |
| 通讯作者 | Zheng, yongtang(zhengyt@mail.kiz.ac.cn) |
| 英文摘要 | Many b cell epitopes within p24 of human immunodeficiency virus type 1 (hiv-1) were identified, while most of them were determined by using murine monoclonal antibodies reacting with overlapping peptides of p24. therefore these epitopes may not represent the actual epitopes recognized by the hiv-1 infected individuals. in the present study, immune responses of 67 hiv-1 positive sera from yunnan province, china to five peptides on p24 of hiv-1 and one of hiv-2 were analyzed. all of 67 sera did not recognize peptide ga-12 on hiv-1 and peptide ag-23 on hiv-2, which indicated that ga-12 was not human b cell epitope and ag-23 did not cross-react with hiv-1 positive serum. except 13 sera (19.4%), all remaining sera did not recognize peptides ni-15, dr-16, dc-22 and ps-18, which indicated that these four peptides represented b cell linear epitopes of hiv-1 p24 in some hiv-1 infected individuals but not the immuno-dominant epitopes in most individuals. |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000208925100007 |
| 出版者 | CHIN SOCIETY IMMUNOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378228 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zheng, Yongtang |
| 作者单位 | 1.Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Yunnan, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Guangjie,Yang, Liumeng,Wang, Jianhua,et al. Immune responses to six synthetic peptides of capsid protein with sera from hiv-1 infected individuals[J]. Cellular & molecular immunology,2005,2(4):289-293. |
| APA | Liu, Guangjie,Yang, Liumeng,Wang, Jianhua,Zhang, Gaohong,Chen, Xiangmei,&Zheng, Yongtang.(2005).Immune responses to six synthetic peptides of capsid protein with sera from hiv-1 infected individuals.Cellular & molecular immunology,2(4),289-293. |
| MLA | Liu, Guangjie,et al."Immune responses to six synthetic peptides of capsid protein with sera from hiv-1 infected individuals".Cellular & molecular immunology 2.4(2005):289-293. |
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来源：中国科学院大学
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