Synthetic peptides derived from sars coronavirus s protein with diagnostic and therapeutic potential
文献类型：期刊论文
| 作者 | Lu, W; Wu, XD; De Shi, M; Yang, RF; He, YY; Bian, C; Shi, TL; Yang, S; Zhu, XL; Jiang, WH |
| 刊名 | Febs letters
 |
| 出版日期 | 2005-04-11 |
| 卷号 | 579期号:10页码:2130-2136 |
| 关键词 | Severe acute respiratory syndrome coronavirus Spike protein Synthetic peptide Syncytia formation and disease prevention |
| ISSN号 | 0014-5793 |
| DOI | 10.1016/j.febslet.2005.02.070 |
| 通讯作者 | Wu, jr() |
| 英文摘要 | The spike (s) protein of severe acute respiratory syndrome coronavirus (sars-cov) is an important viral structural protein. based on bioinformaties analysis, 10 antigenic peptides derived from the s protein sequence were selected and synthesized. the antigenicity and immunoreactivity of all the peptides were tested in vivo and in vitro. four peptides (p6, p8, p9 and p10) which contain b cell epitopes of the s protein were identified, and p8 peptide was confirmed in vivo to have a potential in serological diagnosis. by using a syncytia formation model, we tested the neutralization ability of all 10 peptides and their corresponding antibodies. it is interesting to find that p8 and p9 peptides inhibited syncytia formation, suggesting that the p8 and p9 spanning regions may provide a good target for anti-sars-cov drug design. our data suggest that we have identified peptides derived from the s protein of sars-cov, which are useful for sars treatment and diagnosis. (c) 2005 federation of european biochemical societies. published by elsevier b.v. all rights reserved. |
| WOS关键词 | ACUTE RESPIRATORY SYNDROME ; SPIKE PROTEIN ; IDENTIFICATION ; INFECTION ; SEQUENCE |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000228310700019 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378246 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wu, JR |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Biol Sci, Mol Cell Biol Lab, Grad Sch, Shanghai 200031, Peoples R China 2.Bioinformat Ctr, Shanghai 200031, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Grad Sch, Shanghai 200031, Peoples R China 4.Acad Mil Med Sci, Inst Basic Med Sci, Inst Microbiol & Epidemiol, Beijing 100071, Peoples R China 5.Shanghai Univ, Div Immunol, E Inst, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, W,Wu, XD,De Shi, M,et al. Synthetic peptides derived from sars coronavirus s protein with diagnostic and therapeutic potential[J]. Febs letters,2005,579(10):2130-2136. |
| APA | Lu, W.,Wu, XD.,De Shi, M.,Yang, RF.,He, YY.,...&Sun, B.(2005).Synthetic peptides derived from sars coronavirus s protein with diagnostic and therapeutic potential.Febs letters,579(10),2130-2136. |
| MLA | Lu, W,et al."Synthetic peptides derived from sars coronavirus s protein with diagnostic and therapeutic potential".Febs letters 579.10(2005):2130-2136. |
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来源：中国科学院大学
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