An artificial aspartic proteinase system
文献类型：期刊论文
| 作者 | Jiang, L; Liu, ZL; Liang, Z; Gao, YH |
| 刊名 | Bioorganic & medicinal chemistry
 |
| 出版日期 | 2005-06-01 |
| 卷号 | 13期号:11页码:3673-3680 |
| 关键词 | Crown ether derivatives Carboxyl Aspartic proteinases Artificial enzymes Nucleophilic catalytic mechanism |
| ISSN号 | 0968-0896 |
| DOI | 10.1016/j.bmc.2005.03.026 |
| 通讯作者 | Gao, yh() |
| 英文摘要 | A series of aza crown ether derivatives with or without carboxyl groups in their side arms were synthesized and the former showed deacylation activities toward amino acid p-nitrophenyl ester hydrohalides. substrate-selective phenomena were also observed. the relationship between the structures and deacylation activities of corresponding compounds suggested a nucleophilic catalytic mechanism. the results partially simulate some aspartic proteinases in the case of catalytic mechanism and are also useful for us to understand the detailed catalytic process of aspartic proteinases. (c) 2005 elsevier ltd. all rights reserved. |
| WOS关键词 | IMMUNODEFICIENCY VIRUS-1 PROTEASE ; CHEMICAL MECHANISM ; ELUCIDATE DETAILS ; CRYSTAL-STRUCTURE ; CARBOXYL GROUPS ; PORCINE PEPSIN ; CROWN ETHERS ; ESTER SALTS ; ALPHA-AMINO ; CATALYSIS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000229394300008 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378337 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gao, YH |
| 作者单位 | 1.Chinese Acad Sci, Tech Inst Phys & Chem, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, L,Liu, ZL,Liang, Z,et al. An artificial aspartic proteinase system[J]. Bioorganic & medicinal chemistry,2005,13(11):3673-3680. |
| APA | Jiang, L,Liu, ZL,Liang, Z,&Gao, YH.(2005).An artificial aspartic proteinase system.Bioorganic & medicinal chemistry,13(11),3673-3680. |
| MLA | Jiang, L,et al."An artificial aspartic proteinase system".Bioorganic & medicinal chemistry 13.11(2005):3673-3680. |
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来源：中国科学院大学
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