Studies on subacute biochemical effects of aristolochic acid using h-1 nmr spectroscopy combined with pattern recognition
文献类型：期刊论文
| 作者 | Zhang, XY; Wu, HF; Pei, FK; Ni, JZ |
| 刊名 | Chemical journal of chinese universities-chinese
 |
| 出版日期 | 2005-06-10 |
| 卷号 | 26期号:6页码:991-996 |
| 关键词 | Aristolochic acid Biofluids Nmr Pattern recognition Toxicity |
| ISSN号 | 0251-0790 |
| 通讯作者 | Zhang, xy(cjcu@mail.jlu.edu.cn) |
| 英文摘要 | H-1 nmr spectroscopy and pattern recognition method were used to the studies on the subacute biochemical effects of aristolochic acid (aa). male wistar rats were intraperitoneal with aa for 5 days. urine samples were collected after being treated with aa and the nmr spectra show the nmr marker related to renal papillary and proximal tubular lesion changed greatly. urine samples from the rats treated with model toxins sodium chromate, mercury ii chloride, 2-bromoethanamine hydrobromide, a-naphthylisothiocyanate and hydrazine (nacro4, hgcl2, bea, anit and hyd) were collected over a 48 h time course. each nmr spectrum was data-processed and analyzed by pca methods. a successful classification of the toxicity and biochemical effects of aa was achieved. the biochemical effects and pca classification indicate that the renal toxicity of aa was a progressive course with the accumulation of aa, and caused widespread lesion to kidney including proximal tubule and papillary necrosis. the lesion is irreversible. this method can be used in the toxicological study of other drugs. |
| WOS关键词 | NUCLEAR-MAGNETIC-RESONANCE ; URINE ; CLASSIFICATION ; FIBROSIS ; RATS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000230072500001 |
| 出版者 | HIGHER EDUCATION PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378371 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, XY |
| 作者单位 | Chinese Acad Sci, Changchun Inst Appl Chem, Grad Sch, Key Lab Rare Earth Chem & Phys, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, XY,Wu, HF,Pei, FK,et al. Studies on subacute biochemical effects of aristolochic acid using h-1 nmr spectroscopy combined with pattern recognition[J]. Chemical journal of chinese universities-chinese,2005,26(6):991-996. |
| APA | Zhang, XY,Wu, HF,Pei, FK,&Ni, JZ.(2005).Studies on subacute biochemical effects of aristolochic acid using h-1 nmr spectroscopy combined with pattern recognition.Chemical journal of chinese universities-chinese,26(6),991-996. |
| MLA | Zhang, XY,et al."Studies on subacute biochemical effects of aristolochic acid using h-1 nmr spectroscopy combined with pattern recognition".Chemical journal of chinese universities-chinese 26.6(2005):991-996. |
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来源：中国科学院大学
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