Cloning, expression and characterization of a novel human cap10-like gene hclp46 ftom cd34+stem/progenitor cells
文献类型：期刊论文
| 作者 | Teng, Y; Liu, QH; Ma, H; Liu, F; Han, ZG; Wang, YX; Wang, W |
| 刊名 | Gene
 |
| 出版日期 | 2006-04-12 |
| 卷号 | 371期号:1页码:7-15 |
| 关键词 | Myelodysplastic syndrome Cd34(+) cell Cap10 domain Er retention signal motif Cell growth |
| ISSN号 | 0378-1119 |
| DOI | 10.1016/j.gene.2005.08.027 |
| 通讯作者 | Wang, w() |
| 英文摘要 | A novel human gene, named as human cap10-like protein 46 kda (hclp46), was isolated and identified from human acute myeloid leukemia transformed from myelodysplastic syndrome (mds-aml) cd34(+) cells. hclp46 (3q13.33) contains 11 exons encoding a putative protein of 392 amino acids, with a highly conserved cap10 domain, a hydrophobic signal peptide at its n-terminus, and an endoplasmic reticulum (er) retention signal motif ktel at the c-terminus. the homologs of hclp46 exist in different organisms from plants to animal kingdoms. subcellular localization analysis showed that hclp46 is an er-resident protein. hclp46 expressed in most human adult tissues at different intensities, with lengths of 3.5 kb and 1.9 kb. transcript of hclp46 was not detectable in colon, thymus, and small intestine, but was abundant in liver, indicating that hclp46 may be involved in important physiological functions in the liver. hclp46 over-expressed u937 cells had higher growth rate than the cells without exogenic hclp46 protein expression, suggesting that hclp46 protein possess the ability of promoting cell proliferation. (c) 2006 published by elsevier b.v. |
| WOS关键词 | CAPSULE-ASSOCIATED GENE ; LUMINAL ER PROTEINS ; CRYPTOCOCCUS-NEOFORMANS ; VIRULENCE ; SIGNAL ; ASSOCIATION ; P15(INK4B) ; SEQUENCE ; YEAST |
| WOS研究方向 | Genetics & Heredity |
| WOS类目 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000236947700002 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378496 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, W |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 2.Huazhong Univ Sci & Technol, Tongj Med Coll, Wuhan 430030, Peoples R China 3.Chinese Natl Human Genome Ctr, Shanghai 201203, Peoples R China 4.Chinese Acad Med Sci, Canc Inst & Hosp, Beijing 100021, Peoples R China 5.Capital Univ Med Sci, Sch Publ Hlth & Community Med, Beijing 100054, Peoples R China 6.Edith Cowan Univ, Ctr Human Genet, Perth, WA 6027, Australia |
| 推荐引用方式 GB/T 7714 | Teng, Y,Liu, QH,Ma, H,et al. Cloning, expression and characterization of a novel human cap10-like gene hclp46 ftom cd34+stem/progenitor cells[J]. Gene,2006,371(1):7-15. |
| APA | Teng, Y.,Liu, QH.,Ma, H.,Liu, F.,Han, ZG.,...&Wang, W.(2006).Cloning, expression and characterization of a novel human cap10-like gene hclp46 ftom cd34+stem/progenitor cells.Gene,371(1),7-15. |
| MLA | Teng, Y,et al."Cloning, expression and characterization of a novel human cap10-like gene hclp46 ftom cd34+stem/progenitor cells".Gene 371.1(2006):7-15. |
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来源：中国科学院大学
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