A study of carboxylic-modified i-nesoporous silica in controlled delivery for drug famotidine
文献类型：期刊论文
| 作者 | Tang, QL; Xu, Y; Wu, D; Sun, YH |
| 刊名 | Journal of solid state chemistry
 |
| 出版日期 | 2006-05-01 |
| 卷号 | 179期号:5页码:1513-1520 |
| 关键词 | Mesoporous material Msu Carboxylic-modified Famotidine Controlled drug delivery |
| ISSN号 | 0022-4596 |
| DOI | 10.1016/j.jssc.2006.02.004 |
| 通讯作者 | Xu, y(yhsun@sxicc.ac.cn) |
| 英文摘要 | A series of pure silica msu and carboxylic-modified msu materials were prepared. the formation of mesoporous silica materials with terminal carboxylic groups on pore surface was performed by the acid-catalyzed hydrolysis of cyano to carboxy he. then their potential applications in controlled drug delivery carriers were investigated. drug famotidine was selected as model molecule out of the consideration or the terminal amino groups in its molecule. the adsorption experiments show significant adsorption of famotidine oil the carboxylic-modified msu materials. and, the functionalization level of carboxylic groups has been found to be tire key factor affecting tire adsorption capacities of the modified msu materials for famotidine. subsequently, three kinds of release fluids, including simulated gastric medium, simulated intestinal medium and simulated body fluid, were used to test the famotidine release rate from the carboxylic-modified msu material. obvious delayed effect has been observed for the famotidine release from the carboxylic-modified mesoporous silica material under the in vitro assays. (c) 2006 elsevier inc. all rights reserved. |
| WOS关键词 | MESOPOROUS MOLECULAR-SIEVES ; RELEASE ; MCM-41 ; ADSORPTION ; MATRICES ; EPOXIDATION ; CRYSTAL ; SURFACE ; SPHERES ; ENZYME |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear ; Chemistry, Physical |
| 语种 | 英语 |
| WOS记录号 | WOS:000237528900033 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378649 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Xu, Y |
| 作者单位 | 1.Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Shanxi Province, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, QL,Xu, Y,Wu, D,et al. A study of carboxylic-modified i-nesoporous silica in controlled delivery for drug famotidine[J]. Journal of solid state chemistry,2006,179(5):1513-1520. |
| APA | Tang, QL,Xu, Y,Wu, D,&Sun, YH.(2006).A study of carboxylic-modified i-nesoporous silica in controlled delivery for drug famotidine.Journal of solid state chemistry,179(5),1513-1520. |
| MLA | Tang, QL,et al."A study of carboxylic-modified i-nesoporous silica in controlled delivery for drug famotidine".Journal of solid state chemistry 179.5(2006):1513-1520. |
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来源：中国科学院大学
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