The binding of bmk it2 on mammal and insect sodium channels by surface plasmon resonance assay
文献类型：期刊论文
| 作者 | Chai, Zhi-Fang; Bai, Zhan-Tao; Liu, Tong; Pang, Xue-Yan; Ji, Yong-Hua |
| 刊名 | Pharmacological research
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 54期号:2页码:85-90 |
| 关键词 | Bmk it2 Sodium channels Rat brain synaptosomes Cockroach neuronal membranes Surface plasmon resonance |
| ISSN号 | 1043-6618 |
| DOI | 10.1016/j.phrs.2006.02.009 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | The binding of bmk it2 to insect and mammal sodium channels was investigated by surface plasmon resonance technique. the results showed that bmk it2 could bind not only to cockroach neuronal membranes but also to rat cerebrocortical and hippocampal synaptosomes with distinct affinity. the binding of bmk it2 could be competed significantly by bmk as and bmk abt, but not by aah ii, bmk i and veratridine. furthermore, bmk alpha iv could partially inhibit the binding of bmk it2 to rat cerebrocortical synaptosomes and cockroach neuronal membranes, but not to rat hippocampal synaptosomes. these results suggested that bmk it2 had diverse binding properties on the mammal and insect sodium channels. (c) 2006 elsevier ltd. all rights reserved. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; SELECTIVE SCORPION TOXIN ; ANTI-EPILEPSY PEPTIDE ; MOLECULAR-MECHANISMS ; RECEPTOR-SITES ; NA+ CHANNELS ; RAT-BRAIN ; VENOM ; PURIFICATION ; NEUROTOXIN |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000239738600003 |
| 出版者 | ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378661 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Inst Biol Sci, Shanghai Inst Physiol, Shanghai 200031, Peoples R China 2.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chai, Zhi-Fang,Bai, Zhan-Tao,Liu, Tong,et al. The binding of bmk it2 on mammal and insect sodium channels by surface plasmon resonance assay[J]. Pharmacological research,2006,54(2):85-90. |
| APA | Chai, Zhi-Fang,Bai, Zhan-Tao,Liu, Tong,Pang, Xue-Yan,&Ji, Yong-Hua.(2006).The binding of bmk it2 on mammal and insect sodium channels by surface plasmon resonance assay.Pharmacological research,54(2),85-90. |
| MLA | Chai, Zhi-Fang,et al."The binding of bmk it2 on mammal and insect sodium channels by surface plasmon resonance assay".Pharmacological research 54.2(2006):85-90. |
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来源：中国科学院大学
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