中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Erectile dysfunction in fragile x patients

文献类型:期刊论文

作者Gu, F; Zhang, HY; Hu, SY; Huang, SZ; Ma, X; Zhang, YQ
刊名Asian journal of andrology
出版日期2006-07-01
卷号8期号:4页码:483-487
关键词Fragile x syndrome Fmr1 gene Macroorchidism Erection Fertility Erectile dysfuncion
ISSN号1008-682X
DOI10.1111/j.1745-7262.2006.00156.x
通讯作者Zhang, yq()
英文摘要Aim: to study a possible defect in spermatogenesis of fragile x syndrome (fxs) patients. methods: two different polymerase chain reaction (pcr) based methods were used for the molecular diagnosis of fxs. sperm collection was done mostly according to the laboratory manual of the world health organization. results: we failed to collect sperm samples from five fragile x subjects aged 18-60 years as a result of an unexpected erectile dysfunction (ed). multiple examinations of the same subject at different times, and of different subjects from different provinces by different physicians, showed the same result consistently in all five subjects examined. conclusion: erectile reflex is an instinctive response in all healthy males. the absence of erection can be caused by hormonal, physical or neuronal malfunction. as hormonal profiles were reported to be generally normal in fragile x men, we propose that an unknown physical factor or the neuronal circuit, or both, underlying the erection is compromised. the finding of ed in fragile x patients may help better understand the clinical spectrum and pathogenesis of the disease.
WOS关键词FMR1 KNOCKOUT MICE ; MENTAL-RETARDATION ; FULL MUTATION ; SPERM ; GENE ; SPERMATOGENESIS ; TRANSMISSION ; MOSAICISM ; DIAGNOSIS ; MALES
WOS研究方向Endocrinology & Metabolism ; Urology & Nephrology
WOS类目Andrology ; Urology & Nephrology
语种英语
WOS记录号WOS:000238484900014
出版者BLACKWELL PUBLISHING
URI标识http://www.irgrid.ac.cn/handle/1471x/2378747
专题中国科学院大学
通讯作者Zhang, YQ
作者单位1.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing 100080, Peoples R China
2.Natl Res Inst Family Planning, Dept Genet, Beijing 100081, Peoples R China
3.Peking Union Med Coll, Beijing 100081, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China
5.Chinese Acad Med Sci, Dept Med Genet, Inst Basic Med Sci, Beijing 100005, Peoples R China
6.WHO, Collaborat Ctr Res Human Reprod, Dept Reprod Genet, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Gu, F,Zhang, HY,Hu, SY,et al. Erectile dysfunction in fragile x patients[J]. Asian journal of andrology,2006,8(4):483-487.
APA Gu, F,Zhang, HY,Hu, SY,Huang, SZ,Ma, X,&Zhang, YQ.(2006).Erectile dysfunction in fragile x patients.Asian journal of andrology,8(4),483-487.
MLA Gu, F,et al."Erectile dysfunction in fragile x patients".Asian journal of andrology 8.4(2006):483-487.

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来源:中国科学院大学

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