Erectile dysfunction in fragile x patients
文献类型：期刊论文
| 作者 | Gu, F; Zhang, HY; Hu, SY; Huang, SZ; Ma, X; Zhang, YQ |
| 刊名 | Asian journal of andrology
 |
| 出版日期 | 2006-07-01 |
| 卷号 | 8期号:4页码:483-487 |
| 关键词 | Fragile x syndrome Fmr1 gene Macroorchidism Erection Fertility Erectile dysfuncion |
| ISSN号 | 1008-682X |
| DOI | 10.1111/j.1745-7262.2006.00156.x |
| 通讯作者 | Zhang, yq() |
| 英文摘要 | Aim: to study a possible defect in spermatogenesis of fragile x syndrome (fxs) patients. methods: two different polymerase chain reaction (pcr) based methods were used for the molecular diagnosis of fxs. sperm collection was done mostly according to the laboratory manual of the world health organization. results: we failed to collect sperm samples from five fragile x subjects aged 18-60 years as a result of an unexpected erectile dysfunction (ed). multiple examinations of the same subject at different times, and of different subjects from different provinces by different physicians, showed the same result consistently in all five subjects examined. conclusion: erectile reflex is an instinctive response in all healthy males. the absence of erection can be caused by hormonal, physical or neuronal malfunction. as hormonal profiles were reported to be generally normal in fragile x men, we propose that an unknown physical factor or the neuronal circuit, or both, underlying the erection is compromised. the finding of ed in fragile x patients may help better understand the clinical spectrum and pathogenesis of the disease. |
| WOS关键词 | FMR1 KNOCKOUT MICE ; MENTAL-RETARDATION ; FULL MUTATION ; SPERM ; GENE ; SPERMATOGENESIS ; TRANSMISSION ; MOSAICISM ; DIAGNOSIS ; MALES |
| WOS研究方向 | Endocrinology & Metabolism ; Urology & Nephrology |
| WOS类目 | Andrology ; Urology & Nephrology |
| 语种 | 英语 |
| WOS记录号 | WOS:000238484900014 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378747 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, YQ |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol & Dev Biol, Inst Genet & Dev Biol, Beijing 100080, Peoples R China 2.Natl Res Inst Family Planning, Dept Genet, Beijing 100081, Peoples R China 3.Peking Union Med Coll, Beijing 100081, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 5.Chinese Acad Med Sci, Dept Med Genet, Inst Basic Med Sci, Beijing 100005, Peoples R China 6.WHO, Collaborat Ctr Res Human Reprod, Dept Reprod Genet, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gu, F,Zhang, HY,Hu, SY,et al. Erectile dysfunction in fragile x patients[J]. Asian journal of andrology,2006,8(4):483-487. |
| APA | Gu, F,Zhang, HY,Hu, SY,Huang, SZ,Ma, X,&Zhang, YQ.(2006).Erectile dysfunction in fragile x patients.Asian journal of andrology,8(4),483-487. |
| MLA | Gu, F,et al."Erectile dysfunction in fragile x patients".Asian journal of andrology 8.4(2006):483-487. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。