Semi-parametric accelerated failure time regression analysis with application to interval-censored hiv/aids data
文献类型：期刊论文
| 作者 | Xue, Hongqi; Lam, K. F.; Cowling, Benjamin J.; de Wolf, Frank |
| 刊名 | Statistics in medicine
 |
| 出版日期 | 2006-11-30 |
| 卷号 | 25期号:22页码:3850-3863 |
| 关键词 | Asymptotically efficient Hiv Interval-censored data Partial linear model Sieve maximum likelihood estimator |
| ISSN号 | 0277-6715 |
| DOI | 10.1002/sim.2486 |
| 通讯作者 | Lam, k. f.(hrntlkf@hku.hk) |
| 英文摘要 | This paper demonstrates a way to investigate a potentially non-linear relationship between an interval-censored response variable and a continuously distributed explanatory variable. a potentially non-linear effect of a continuous explanatory variable on the response is incorporated into an accelerated failure time model, forming a partial linear model. a sieve maximum likelihood estimator (mle) is suggested to simultaneously estimate all the parameters. the sieve mle is shown to be asymptotically efficient and normally distributed. simulation studies show that the proposed estimators for the scale and regression parameters are robust and efficient, and the estimator for the non-linear function is able to capture the shape of a variety of smooth non-linear functions. the model is applied to observational hiv data, where the response variable is the time to suppression of hiv viral load after initiation of antiretroviral therapy, and baseline viral load is investigated as a potentially non-linear effect. copyright (c) 2005 john wiley & sons, ltd. |
| WOS关键词 | ANTIRETROVIRAL THERAPY ; VIROLOGICAL RESPONSE ; LINEAR-REGRESSION ; HIV-1 ; PROGRESSION ; PREDICTORS ; MORTALITY ; PLASMA ; MODEL ; AIDS |
| WOS研究方向 | Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Research & Experimental Medicine ; Mathematics |
| WOS类目 | Mathematical & Computational Biology ; Public, Environmental & Occupational Health ; Medical Informatics ; Medicine, Research & Experimental ; Statistics & Probability |
| 语种 | 英语 |
| WOS记录号 | WOS:000242429400006 |
| 出版者 | JOHN WILEY & SONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378790 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Lam, K. F. |
| 作者单位 | 1.Univ Hong Kong, Dept Stat & Actuarial Sci, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Dept Math, Grad Univ, Beijing, Peoples R China 3.Univ Amsterdam, HIV Monitoring Fdn, Amsterdam, Netherlands 4.Univ London Imperial Coll Sci Technol & Med, Dept Infect Dis Epidemiol, London, England |
| 推荐引用方式 GB/T 7714 | Xue, Hongqi,Lam, K. F.,Cowling, Benjamin J.,et al. Semi-parametric accelerated failure time regression analysis with application to interval-censored hiv/aids data[J]. Statistics in medicine,2006,25(22):3850-3863. |
| APA | Xue, Hongqi,Lam, K. F.,Cowling, Benjamin J.,&de Wolf, Frank.(2006).Semi-parametric accelerated failure time regression analysis with application to interval-censored hiv/aids data.Statistics in medicine,25(22),3850-3863. |
| MLA | Xue, Hongqi,et al."Semi-parametric accelerated failure time regression analysis with application to interval-censored hiv/aids data".Statistics in medicine 25.22(2006):3850-3863. |
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来源：中国科学院大学
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