Nanogp8 is a retrogene expressed in cancers
文献类型：期刊论文
| 作者 | Zhang, JY; Wang, X; Li, MX; Han, J; Chen, B; Wang, B; Dai, JW |
| 刊名 | Febs journal
 |
| 出版日期 | 2006-04-01 |
| 卷号 | 273期号:8页码:1723-1730 |
| 关键词 | Nanog Nanogp8 Pseudogene Retrogene Tumorigenesis |
| ISSN号 | 1742-464X |
| DOI | 10.1111/j.1742-4658.2006.05186.x |
| 通讯作者 | Dai, jw() |
| 英文摘要 | Nanog is a transcription factor that plays key roles in the self-renewal and maintenance of pluripotency in human embryonic stem (es) cells. among nanog's 11 pseudogenes, nanogp8 theoretically could be a retrogene, but was considered unlikely as it has not been identified in any expressed sequence tags (ests). in this study, we found that nanogp8 was expressed in several cancer cell lines and in all cancer tissues tested. the complete coding sequence was cloned and the sequence is highly homologous to that of nanog. we were also able to detect its protein expression using anti-nanog antibody in recombinant escherichia coli and some cancer cell lines tested. in addition, expression of nanogp8 in nih3t3 cells can promote cell proliferation. the expression of nanogp8 in cancer cell lines and cancer tissues suggests that nanogp8 may play important roles in tumorigenesis. this work not only has potential significance in stem cell and cancer research, but it also raises the possibility that some of the human pseudogenes may have regulatory functions. |
| WOS关键词 | MESSENGER-RNA STABILITY ; HOMOLOGOUS CODING GENE ; EMBRYONIC STEM-CELLS ; PSEUDOGENES ; IDENTIFICATION ; PLURIPOTENCY ; OCT4 ; PROLIFERATION ; CARCINOMA ; PROTEIN |
| WOS研究方向 | Biochemistry & Molecular Biology |
| WOS类目 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000236394100013 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378823 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, JW |
| 作者单位 | 1.Chinese Acad Sci, Mol & Dev Biol Lab, Inst Genet & Dev Biol, Beijing, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, JY,Wang, X,Li, MX,et al. Nanogp8 is a retrogene expressed in cancers[J]. Febs journal,2006,273(8):1723-1730. |
| APA | Zhang, JY.,Wang, X.,Li, MX.,Han, J.,Chen, B.,...&Dai, JW.(2006).Nanogp8 is a retrogene expressed in cancers.Febs journal,273(8),1723-1730. |
| MLA | Zhang, JY,et al."Nanogp8 is a retrogene expressed in cancers".Febs journal 273.8(2006):1723-1730. |
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来源：中国科学院大学
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