Study on the interaction of porphyrin with G-quadruplex DNAs
文献类型：期刊论文
| 作者 | Wei, Chunying1; Han, Gaoyi1; Jia, Guoqing2; Zhou, Jun2; Li, Can2 |
| 刊名 | biophysical chemistry
 |
| 出版日期 | 2008-09-01 |
| 卷号 | 137期号:1页码:19-23 |
| 关键词 | G-quadruplexes porphyrin spectroscopy interaction |
| 产权排序 | 2;3 |
| 通讯作者 | 李灿 |
| 英文摘要 | interactions of 5,10,15,20-tetrakis(n-propylpyridinium-4-yl)-21h,23h-porphyrin (tprpyp4) with dimer hairpin (g(4)t(4)g(4))2 and parallel four-stranded (tg(4)t)4 g-quadruplex dnas in na+-containing buffer were studied. the results show that two tprpyp4 molecules bind to both g-quadruplexes by a noncooperative and nonequivalent binding mode, and there are one high affinity site and one low affinity site, the respective binding constants are 8.06 x 10(8) and 1.13 x 10(6) m-1 for (g(4)t(4)g(4))2-tprpyp4, 8.04 x 10(7) and 9.08 x 10(5)m(-1) for (tg(4)t)4-tprpyp4. tprpyp4 presents two lifetimes of about 5.8 and 12.0 ns in the complexes cf g-quadruplexes-tprpyp4. the primary results suggest that two tprpyp4 molecules bind to both g-quadruplexes by terminal stacking and outside binding mode. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemistry & molecular biology ; biophysics ; chemistry, physical |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics ; chemistry |
| 关键词[WOS] | cationic porphyrins ; structural basis ; ligand-binding ; telomeric dna ; complexes ; stabilization ; fluorescence ; selectivity |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000258890800004 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101279]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Shanxi Univ, Inst Mol Sci, Key Lab Chem Biol & Mol Engn, Minist Educ, Taiyuan 030006, Peoples R China 2.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Chunying,Han, Gaoyi,Jia, Guoqing,et al. Study on the interaction of porphyrin with G-quadruplex DNAs[J]. biophysical chemistry,2008,137(1):19-23. |
| APA | Wei, Chunying,Han, Gaoyi,Jia, Guoqing,Zhou, Jun,&Li, Can.(2008).Study on the interaction of porphyrin with G-quadruplex DNAs.biophysical chemistry,137(1),19-23. |
| MLA | Wei, Chunying,et al."Study on the interaction of porphyrin with G-quadruplex DNAs".biophysical chemistry 137.1(2008):19-23. |
入库方式： OAI收割
来源：大连化学物理研究所
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