The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions
文献类型：期刊论文
| 作者 | Zhou, Jun1,2; Wei, Chunying1; Jia, Guoqing1,2; Wang, Xiuli1,2; Tang, Qian3; Feng, Zhaochi1; Li, Can1 |
| 刊名 | biophysical chemistry
 |
| 出版日期 | 2008-08-01 |
| 卷号 | 136期号:2-3页码:124-127 |
| 关键词 | human telomeric G-quadruplex molecular crowding excluded volume effect structural transition compaction |
| 产权排序 | 1;1 |
| 通讯作者 | 李灿 |
| 英文摘要 | the structure polymorphism of human telomeric g-cluadruplex (ht-quadruplex) is currently an important topic but remains controversy. here, we present study of the ht-cluadruplex under the cation-deficient but molecular crowding conditions by circular dichroism (cd), microchip electrophoresis (mce) and uv-melting experiments. our results show that with concentration increasing of poly(ethylene glycol) (peg), the structural transition of ht-quadruplex occurs accompanied by structural compaction and enhanced stabilization, which may be caused by excluded volume effect. this work also demonstrates that htquadruplex can be well assembled without cations and the structure of ht-quadruplex is actually very complex in vivo. (c) 2008 elsevier b.v. all rights reserved. |
| WOS标题词 | science & technology ; life sciences & biomedicine ; physical sciences |
| 类目[WOS] | biochemistry & molecular biology ; biophysics ; chemistry, physical |
| 研究领域[WOS] | biochemistry & molecular biology ; biophysics ; chemistry |
| 关键词[WOS] | molecular crowding conditions ; intramolecular g-quadruplex ; quartet structures ; dna ; sequence ; stability ; targets ; media ; forms ; acid |
| 收录类别 | SCI |
| 原文出处 | true |
| 语种 | 英语 |
| WOS记录号 | WOS:000257821400008 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101281]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Dalian Univ Technol, Bioengn Coll, Dalian 116622, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Jun,Wei, Chunying,Jia, Guoqing,et al. The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions[J]. biophysical chemistry,2008,136(2-3):124-127. |
| APA | Zhou, Jun.,Wei, Chunying.,Jia, Guoqing.,Wang, Xiuli.,Tang, Qian.,...&Li, Can.(2008).The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions.biophysical chemistry,136(2-3),124-127. |
| MLA | Zhou, Jun,et al."The structural transition and compaction of human telomeric G-quadruplex induced by excluded volume effect under cation-deficient conditions".biophysical chemistry 136.2-3(2008):124-127. |
入库方式： OAI收割
来源：大连化学物理研究所
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