An ionotropic gaba receptor with novel pharmacology at bullfrog cone photoreceptor terminals
文献类型：期刊论文
| 作者 | Liu, Jian; Li, Geng-Lin; Yang, Xiong-Li |
| 刊名 | Neurosignals
 |
| 出版日期 | 2006 |
| 卷号 | 15期号:1页码:13-25 |
| 关键词 | Bicuculline Cone photoreceptor Chloride channel Ionotropic gaba receptor Retina Bullfrog |
| ISSN号 | 1424-862X |
| DOI | 10.1159/000094384 |
| 通讯作者 | Yang, xiong-li(xlyang@fudan.edu.cn) |
| 英文摘要 | Characteristics of ionotropic gamma-aminobutyric acid (gaba) receptors at bullfrog cone terminals were studied by patch clamp techniques in isolated cell and retinal slice preparations. gaba-induced inward currents from isolated cones reversed in polarity at a potential, very close to the chloride equilibrium potential, and they were completely suppressed by picrotoxin. unexpectedly, the gaba current was dose-dependently potentiated by the well-known gaba(a) receptor antagonist bicuculline (bic), but was suppressed by gabazine, another gabaa antagonist, and imidazole-4-acetic acid (i4aa), a gaba(c) receptor antagonist. similarly, currents induced by both gabaa agonist muscimol and gaba(c) agonist cis-4-aminocrotonic acid (caca) were also potentiated by bic. furthermore, currents induced from cones by gaba and kainate-caused depolarization of horizontal cells in retinal slice preparations were both potentiated by bic. all these results suggest that the ionotropic gaba receptor at the bullfrog cone terminal exhibits novel pharmacology, distinct from both traditional gabaa and gabac receptors. copyright (c) 2006 s. karger ag, basel. |
| WOS关键词 | TIGER SALAMANDER RETINA ; GAMMA-AMINOBUTYRIC-ACID ; WHITE PERCH RETINA ; OUTER PLEXIFORM LAYER ; HORIZONTAL CELLS ; RABBIT RETINA ; RHO SUBUNITS ; A RECEPTOR ; RESPONSE KINETICS ; HILL COEFFICIENT |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology ; Neurosciences & Neurology |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology ; Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000239724100002 |
| 出版者 | KARGER |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378905 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Xiong-Li |
| 作者单位 | 1.Fudan Univ, Inst Neurobiol, Inst Brain Sci, Shanghai 200433, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Shanghai, Peoples R China 3.Chinese Acad Sci, Grad Sch, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jian,Li, Geng-Lin,Yang, Xiong-Li. An ionotropic gaba receptor with novel pharmacology at bullfrog cone photoreceptor terminals[J]. Neurosignals,2006,15(1):13-25. |
| APA | Liu, Jian,Li, Geng-Lin,&Yang, Xiong-Li.(2006).An ionotropic gaba receptor with novel pharmacology at bullfrog cone photoreceptor terminals.Neurosignals,15(1),13-25. |
| MLA | Liu, Jian,et al."An ionotropic gaba receptor with novel pharmacology at bullfrog cone photoreceptor terminals".Neurosignals 15.1(2006):13-25. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。