Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur
文献类型：期刊论文
| 作者 | Lu, Xiao-Mei; Yang, Ting; Xu, Shu-Yong; Wen, Hao; Wang, Xing; Ren, Zhi-Hui; Zhang, Yan; Wang, Wei |
| 刊名 | World journal of gastroenterology
 |
| 出版日期 | 2006-12-28 |
| 卷号 | 12期号:48页码:7758-7761 |
| 关键词 | Glutathione-s-transferase m1 Kazakh Uygur Tajik Esophageal cancer |
| ISSN号 | 1007-9327 |
| 通讯作者 | Wang, wei() |
| 英文摘要 | Aim: to investigate the glutathione-s-transferase m1 (gstm1) polymorphisms in three chinese minorities, kazakh, uygur, and tajik; and the pathological significance of gstm1 polymorphisms in esophageal carcinogenesis in kazakh. methods: a total of 1121 blood samples (442 males and 679 females) were obtained from healthy kazakh (654), uygur (412) and tajik (55). primary esophageal squamous cell cancer (escc) tissues from kazakh were obtained from 116 patients who underwent surgery. gstm1 polymorphisms were analyzed by a combined approach of pcr and electrophoresis techniques. results: gstm1 null genotype was found in 62.63% uygur, 50.91% tajik and 47.40% kazakh. a significantly higher frequency of gstm1 null genotype in uygur was observed compared with kazakh (or: 1.859, 95% ci: 1.445 -2.391, chi(2) = 23.71, p = 0.000). in addition, gstm1 null genotype was found in 23.53% of well-differentiated escc in kazakh, in 49.23% of poorly differentiated escc, with a significant difference (or: 3.152, 95% ci: 1.403-7.080, chi(2) = 8.018, p = 0.007). conclusion: there is a marked difference in the frequency of common gstm1 null genotype between uygur and kazakh. gstm1 null genotype is associated with differentiation of escc in kazakh. (c) 2006 the wjg press. all rights reserved. |
| WOS关键词 | GENETIC POLYMORPHISMS ; BLADDER-CANCER ; NULL GENOTYPE ; GSTT1 POLYMORPHISMS ; INCREASED RISK ; GSTM1 ; METAANALYSIS ; ASSOCIATION ; GSTP1 ; T1 |
| WOS研究方向 | Gastroenterology & Hepatology |
| WOS类目 | Gastroenterology & Hepatology |
| 语种 | 英语 |
| WOS记录号 | WOS:000243309900005 |
| 出版者 | W J G PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2378998 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wang, Wei |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Dept Biol, Beijing 100049, Peoples R China 2.Xinjiang Med Univ, Teaching Hosp 1, Med Res Ctr, Urumqi 830054, Xinjiang, Peoples R China 3.Xinjiang Med Univ, Basic Med Coll, Urumqi 830054, Xinjiang Uygur, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Xiao-Mei,Yang, Ting,Xu, Shu-Yong,et al. Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur[J]. World journal of gastroenterology,2006,12(48):7758-7761. |
| APA | Lu, Xiao-Mei.,Yang, Ting.,Xu, Shu-Yong.,Wen, Hao.,Wang, Xing.,...&Wang, Wei.(2006).Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur.World journal of gastroenterology,12(48),7758-7761. |
| MLA | Lu, Xiao-Mei,et al."Glutathione-s-transferase m1 polymorphisms on the susceptibility to esophageal cancer among three chinese minorities: kazakh, tajik and uygur".World journal of gastroenterology 12.48(2006):7758-7761. |
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来源：中国科学院大学
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