The interaction and toxicity of multi-walled carbon nanotubes with stylonychia mytilus
文献类型：期刊论文
| 作者 | Zhu, Y; Zhao, QF; Li, YG; Cai, XQ; Li, W |
| 刊名 | Journal of nanoscience and nanotechnology
 |
| 出版日期 | 2006-05-01 |
| 卷号 | 6期号:5页码:1357-1364 |
| ISSN号 | 1533-4880 |
| 关键词 | Stylonychia mytilus Multi-walled carbon nanotubes (mwnts) Metabolism Toxicity Mitochondrion |
| DOI | 10.1166/jnn.2006.194 |
| 通讯作者 | Li, w() |
| 英文摘要 | The interaction of multi-walled carbon nanotubes (mwnts) with living unicellular protozoan stylonychia mytilus was studied. the results indicated that mwnts were ingested largely by stylonychia mytilus. distribution of mwnts in the cells, redistribution during dividing process of the cells, and excretion from the cells were observed successfully with optical microscope. the dependence of viability of stylonychia mytilus was determined on the concentration of mwnts, ranging from 0.1 mu g/ml to 200 mu g/ml. it was found that exposure of stylonychia mytilus to the mwnts with concentration higher than 1.0 mu g/ml induced a dose-dependent growth inhibition to the cells and the damage occurred, by fluorescence microscopy, on the macronucleus and external membrane of the cells. the ultrastructure change by electron microscope revealed that the mwnts exclusively localized to the mitochondria of the cells. it was proposed that the damage of macronucleus, micronucleus, and membrane of the cells, as well as growth inhibition of the cells might be a result of the damage of mitochondria, following this exclusive localization. our finding provides important information on the bio-security of mwnts and their migration in aqueous environment. |
| WOS关键词 | PULMONARY TOXICITY ; CYTOTOXICITY ; FULLERENE ; CELLS ; MICE |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 语种 | 英语 |
| 出版者 | AMER SCIENTIFIC PUBLISHERS |
| WOS记录号 | WOS:000238030200022 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379023 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Li, W |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Lab Nanobiol & Med, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Ningbo Univ, Coll Life Sci & Bioengn, Ningbo 315211, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Y,Zhao, QF,Li, YG,et al. The interaction and toxicity of multi-walled carbon nanotubes with stylonychia mytilus[J]. Journal of nanoscience and nanotechnology,2006,6(5):1357-1364. |
| APA | Zhu, Y,Zhao, QF,Li, YG,Cai, XQ,&Li, W.(2006).The interaction and toxicity of multi-walled carbon nanotubes with stylonychia mytilus.Journal of nanoscience and nanotechnology,6(5),1357-1364. |
| MLA | Zhu, Y,et al."The interaction and toxicity of multi-walled carbon nanotubes with stylonychia mytilus".Journal of nanoscience and nanotechnology 6.5(2006):1357-1364. |
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来源：中国科学院大学
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