The epileptic seizures induced by bmk i, a modulator of sodium channels
文献类型：期刊论文
| 作者 | Bai, ZT; Zhao, R; Zhang, XY; Chen, J; Liu, T; Ji, YH |
| 刊名 | Experimental neurology
 |
| 出版日期 | 2006 |
| 卷号 | 197期号:1页码:167-176 |
| 关键词 | Bmk i Intrahippocampal injection Epileptic seizures C-fos expression Voltage-gated sodium channels |
| ISSN号 | 0014-4886 |
| DOI | 10.1016/j.expneurol.2005.09.006 |
| 通讯作者 | Ji, yh() |
| 英文摘要 | In the present study, the susceptibility to rat epileptic seizures induced by the intrahippocampal administration of bmk 1, a modulator of sodium channels purified from the venom of chinese scorpion, has been investigate(]. the results showed that the strong epileptic behaviors and discharges in the hippocampus were evoked by bmk i dose-dependently. the hippocampal c-fos expression displayed two peak waves in a specific spatio-temporal pattern elicited by bmk 1. the whole cell patch clamp recordings showed that the inactivation of sodium currents in rat cultured hippocampal neurons was prolonged significantly by bmk 1, and restored partially after washing. these results indicated that the rat hippocampus is a susceptible target for the proconvulsant effects of bmk 1, and the induction of epileptic seizures may be ascribed to the modulation of bmk i on the inactivation of voltage-gated sodium channels distributing in the rat hippocampal neurons. (c) 2005 elsevier inc. all rights reserved. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; SERRULATUS SCORPION-VENOM ; C-FOS EXPRESSION ; GENERALIZED EPILEPSY ; FEBRILE SEIZURES ; SPINAL-CORD ; LIMBIC SEIZURES ; NERVOUS-SYSTEM ; TRANSCRIPTION FACTORS ; POSSIBLE MECHANISM |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000234534200017 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379026 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, YH |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200436, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Grad Sch, Shanghai 200031, Peoples R China 3.Yanan Univ, Coll Life Sci, Yanan 716000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, ZT,Zhao, R,Zhang, XY,et al. The epileptic seizures induced by bmk i, a modulator of sodium channels[J]. Experimental neurology,2006,197(1):167-176. |
| APA | Bai, ZT,Zhao, R,Zhang, XY,Chen, J,Liu, T,&Ji, YH.(2006).The epileptic seizures induced by bmk i, a modulator of sodium channels.Experimental neurology,197(1),167-176. |
| MLA | Bai, ZT,et al."The epileptic seizures induced by bmk i, a modulator of sodium channels".Experimental neurology 197.1(2006):167-176. |
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来源：中国科学院大学
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