Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies
文献类型：期刊论文
| 作者 | Wu, CT; Chang, JA; Zhai, WY; Ni, SY; Wang, JY |
| 刊名 | Journal of biomedical materials research part b-applied biomaterials
 |
| 出版日期 | 2006-07-01 |
| 卷号 | 78b期号:1页码:47-55 |
| 关键词 | Akermanite scaffolds Bioactive Degradable Alp Cytocompatible |
| ISSN号 | 1552-4973 |
| DOI | 10.1002/jbm.b.30456 |
| 通讯作者 | Chang, ja() |
| 英文摘要 | The aim of this study was to develop a bioactive, degradable, and cytocompatible akermanite (ca2mgsi2o7) scaffold with high porosity and pore interconnectivity. in brief, porous akermanite scaffolds were prepared using polymer sponge method. the porosity and corresponding compressive strength were evaluated. the in vitro degradability was investigated by soaking the scaffolds in ringer's solution. hydroxyapatite (hap)-formation ability of akermantite scaffolds in simulated body fluid (sbf) and the effect of ionic products from the scaffolds dissolution on osteoblasts were investigated. in addition, bone marrow stromal cells (bmsc) adhesion and proliferation on the scaffolds were evaluated. differentiation of the cells was assessed by measuring alkaline phosphatase (alp) activity. the results showed that akermanite scaffolds possessed 63.5-90.3% of porosity, with a corresponding compressive strength between 1130 and 530 kpa. the weight loss of the scaffolds and ionic content of the ringer's solution increased with the increase in soaking time, indicating the degradability of scaffolds. hap was formed on the scaffolds in sbf and the ionic products from akermanite scaffolds dissolution stimulated osteoblasts proliferation, indicating good in vitro bioactivity. furthermore, bmsc adhered and spread well on akermanite scaffolds and proliferated with the increase in the culture time, and the differentiation rate of osteoblasts on scaffolds was comparable to that on blank culture plate control. our results suggested that akermanite scaffolds were bioactive, degradable, and cytocompatible, and might be used as bone tissue lengineering materials. (c) 2005 wiley periodicals, inc. |
| WOS关键词 | BIOACTIVE GLASS ; IONIC PRODUCTS ; APATITE LAYER ; HYDROXYAPATITE ; BIOMATERIALS ; CERAMICS ; PROLIFERATION ; DISSOLUTION ; DIOPSIDE ; ADHESION |
| WOS研究方向 | Engineering ; Materials Science |
| WOS类目 | Engineering, Biomedical ; Materials Science, Biomaterials |
| 语种 | 英语 |
| WOS记录号 | WOS:000238737300007 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379044 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chang, JA |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Ceram, Biomat & Tissue Engn Res Ctr, Shanghai 200050, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.E China Normal Univ, Sch Biol Sci, Shanghai 200062, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, CT,Chang, JA,Zhai, WY,et al. Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies[J]. Journal of biomedical materials research part b-applied biomaterials,2006,78b(1):47-55. |
| APA | Wu, CT,Chang, JA,Zhai, WY,Ni, SY,&Wang, JY.(2006).Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies.Journal of biomedical materials research part b-applied biomaterials,78b(1),47-55. |
| MLA | Wu, CT,et al."Porous akermanite scaffolds for bone tissue engineering: preparation, characterization, and in vitro studies".Journal of biomedical materials research part b-applied biomaterials 78b.1(2006):47-55. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。