Disruption of lipid rafts impairs the production of nitric oxide in lipopolysaccharide-stimulated murine raw264.7 macrophages
文献类型：期刊论文
| 作者 | Zhang, Shen; Jin, Huajun; Zhou, Juefei; Wei, Taotao |
| 刊名 | Research on chemical intermediates
 |
| 出版日期 | 2006 |
| 卷号 | 32期号:9页码:847-856 |
| ISSN号 | 0922-6168 |
| 关键词 | Raw 264.7 macrophage Nitric oxide Lipopolysaccharide Inos Nf-kappa b Lipid raft Methyl-beta-cyclodextrin |
| 通讯作者 | Wei, taotao(weitt@moon.ibp.ac.cn) |
| 英文摘要 | Upon stimulation with lipopolysaccharide, murine raw264.7 macrophages generated a high amount of nitric oxide. pretreatment of macrophages with methyl-beta-cyclodextrin, which disrupted the lipid raft microdomains of the plasma membrane, inhibited the generation of nitric oxide by down-regulating the expression of inducible nitric oxide synthase. methyl-beta-cyclodextrin exposure significantly inhibited the degradation of i kappa b-alpha, blocked the translocation of p65/rela into the nuclei and prevented the activation of the nf-kappa b signaling pathway. the results suggest that the expression of inducible nitric oxide synthase and the consequent production of nitric oxide depend on the integrity of the lipid rafts. |
| WOS关键词 | CYCLODEXTRIN DERIVATIVES ; CELL BIOLOGY ; DISEASE ; RECOGNITION ; CHOLESTEROL ; ACTIVATION ; PATHOGENS ; DOMAINS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| 出版者 | VSP BV |
| WOS记录号 | WOS:000243596100005 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379067 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Wei, Taotao |
| 作者单位 | 1.Chinese Acad Sci, Ctr Struct & Mol Biol, Inst Biophys, Beijing 100101, Peoples R China 2.Huaihua Med Coll, Dept Lab Med, Huaihua 418000, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shen,Jin, Huajun,Zhou, Juefei,et al. Disruption of lipid rafts impairs the production of nitric oxide in lipopolysaccharide-stimulated murine raw264.7 macrophages[J]. Research on chemical intermediates,2006,32(9):847-856. |
| APA | Zhang, Shen,Jin, Huajun,Zhou, Juefei,&Wei, Taotao.(2006).Disruption of lipid rafts impairs the production of nitric oxide in lipopolysaccharide-stimulated murine raw264.7 macrophages.Research on chemical intermediates,32(9),847-856. |
| MLA | Zhang, Shen,et al."Disruption of lipid rafts impairs the production of nitric oxide in lipopolysaccharide-stimulated murine raw264.7 macrophages".Research on chemical intermediates 32.9(2006):847-856. |
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来源：中国科学院大学
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