Transforming growth factor-beta: an important role in cd4(+) cd25(+) regulatory t cells and immune tolerance
文献类型：期刊论文
| 作者 | Zhang, Lianjun; Yi, Huanfa; Xia, Xue-Pei; Zhao, Yong |
| 刊名 | Autoimmunity
 |
| 出版日期 | 2006-06-01 |
| 卷号 | 39期号:4页码:269-276 |
| 关键词 | Transforming growth factor-beta Foxp3 Regulatory t cells Immune tolerance |
| ISSN号 | 0891-6934 |
| DOI | 10.1080/08916930600753903 |
| 通讯作者 | Zhao, yong(zhaoy@ioz.ac.cn) |
| 英文摘要 | The transforming growth factor-beta (tgf-beta) protein family is highly evolutionarily conserved and they have been implicated in many biological processes. also, tgf-beta can exert pivotal functions in the immune system. it is widely accepted that regulatory t cells (treg cells) play an important role in the maintenance of the immune homeostasis, but the underlying molecular mechanisms through which they can gain and/or perform suppressive functions in an active way remains to be defined. though the engagement of tgf-beta in the treg cells has been discounted for a period of time, an emerging body of data has established a close link between treg cells and tgf-beta, as tgf-beta has been demonstrated to induce the expression of foxp3, which acts as a master regulator for the development and function of treg cells. we will, herein, focus on the crucial role of tgf-beta signaling in treg cell biology and summarize the current studies regarding tgf-beta in the generation and function of cd4 + cd25 + treg cells both in vivo and in vitro . |
| WOS关键词 | IMMUNOLOGICAL SELF-TOLERANCE ; TRANSCRIPTION FACTOR FOXP3 ; IN-VIVO EXPANSION ; LIGASE CBL-B ; TGF-BETA ; CUTTING EDGE ; DENDRITIC CELLS ; AUTOIMMUNE-DISEASES ; SUPPRESSOR FUNCTION ; TGF-BETA-1 |
| WOS研究方向 | Immunology |
| WOS类目 | Immunology |
| 语种 | 英语 |
| WOS记录号 | WOS:000239566900002 |
| 出版者 | TAYLOR & FRANCIS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379132 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhao, Yong |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Biomembrane & Membrane Biotechnol, Inst Zool, Transplantat Biol Res Div, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Beijing Haidian Hosp, Dept Endocrinol, Beijing, Peoples R China 4.Univ Nebraska, Med Ctr, Dept Pharmacol & Expt Neurosci, Omaha, NE 68182 USA |
| 推荐引用方式 GB/T 7714 | Zhang, Lianjun,Yi, Huanfa,Xia, Xue-Pei,et al. Transforming growth factor-beta: an important role in cd4(+) cd25(+) regulatory t cells and immune tolerance[J]. Autoimmunity,2006,39(4):269-276. |
| APA | Zhang, Lianjun,Yi, Huanfa,Xia, Xue-Pei,&Zhao, Yong.(2006).Transforming growth factor-beta: an important role in cd4(+) cd25(+) regulatory t cells and immune tolerance.Autoimmunity,39(4),269-276. |
| MLA | Zhang, Lianjun,et al."Transforming growth factor-beta: an important role in cd4(+) cd25(+) regulatory t cells and immune tolerance".Autoimmunity 39.4(2006):269-276. |
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来源：中国科学院大学
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