The yeast prion protein ure2: structure, function and folding
文献类型：期刊论文
| 作者 | Lian, HY; Jiang, Y; Zhang, H; Jones, GW; Perrett, S |
| 刊名 | Biochimica et biophysica acta-proteins and proteomics
 |
| 出版日期 | 2006-03-01 |
| 卷号 | 1764期号:3页码:535-545 |
| 关键词 | Prion Amyloid Glutathione transferase Peroxidase Protein folding Chaperone |
| ISSN号 | 1570-9639 |
| DOI | 10.1016/j.bbapap.2005.11.016 |
| 通讯作者 | Perrett, s() |
| 英文摘要 | The saccharomyces cerevisiae protein ure2 functions as a regulator of nitrogen metabolism and as a glutathione-dependent peroxidase. ure2 also has the characteristics of a prion, in that it can undergo a heritable conformational change to an aggregated state,, the prion form of ure2 loses the regulatory function, but the enzymatic function appears to be maintained. a number of factors are found to affect the prion properties of ure2, including mutation and expression levels of molecular chaperones, and the effect of these factors oil structure and stability are being investigated. the relationship between structure, function and folding for the yeast prion ure2 are discussed. (c) 2005 elsevier b.v. all rights reserved. |
| WOS关键词 | GLUTATHIONE-S-TRANSFERASE ; HEAVY-METAL ION ; SACCHAROMYCES-CEREVISIAE ; IN-VITRO ; NEURODEGENERATIVE DISEASES ; POLYGLUTAMINE AGGREGATION ; ANTAGONISTIC INTERACTIONS ; MOLECULAR CHAPERONES ; INFECTIOUS PROTEIN ; PODOSPORA-ANSERINA |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000236839300024 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379298 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Perrett, S |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Natl Univ Ireland, Dept Biol, Maynooth, Kildare, Ireland |
| 推荐引用方式 GB/T 7714 | Lian, HY,Jiang, Y,Zhang, H,et al. The yeast prion protein ure2: structure, function and folding[J]. Biochimica et biophysica acta-proteins and proteomics,2006,1764(3):535-545. |
| APA | Lian, HY,Jiang, Y,Zhang, H,Jones, GW,&Perrett, S.(2006).The yeast prion protein ure2: structure, function and folding.Biochimica et biophysica acta-proteins and proteomics,1764(3),535-545. |
| MLA | Lian, HY,et al."The yeast prion protein ure2: structure, function and folding".Biochimica et biophysica acta-proteins and proteomics 1764.3(2006):535-545. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。