Prevalence and genetic diversity of coronaviruses in bats from china
文献类型：期刊论文
| 作者 | Tang, X. C.; Zhang, J. X.; Zhang, S. Y.; Wang, P.; Fan, X. H.; Li, L. F.; Li, G.; Dong, B. Q.; Liu, W.; Cheung, C. L. |
| 刊名 | Journal of virology
 |
| 出版日期 | 2006-08-01 |
| 卷号 | 80期号:15页码:7481-7490 |
| ISSN号 | 0022-538X |
| DOI | 10.1128/jvi.00697-06 |
| 通讯作者 | Chen, h.(hlchen@hku.hk) |
| 英文摘要 | Coronaviruses can infect a variety of animals including poultry, livestock, and humans and are currently classified into three groups. the interspecies transmissions of coronaviruses between different hosts form a complex ecosystem of which little is known. the outbreak of severe acute respiratory syndrome (sars) and the recent identification of new coronaviruses have highlighted the necessity for further investigation of coronavirus ecology, in particular the role of bats and other wild animals. in this study, we sampled bat populations in 15 provinces of china and reveal that approximately 6.5% of the bats, from diverse species distributed throughout the region, harbor coronaviruses. full genomes of four coronavirues from bats were sequenced and analyzed. phylogenetic analyses of the spike, envelope, membrane, and nucleoprotein structural proteins and the two conserved replicase domains, putative rna-dependent rna polymerase and rna hellicase, revealed that bat coronaviruses cluster in three different groups: group 1, another group that includes all sars and sars-like coronaviruses (putative group 4), and an independent bat coronavirus group (putative group 5). further genetic analyses showed that different species of bats maintain coronaviruses from different groups and that a single bat species from different geographic locations supports similar coronaviruses. thus, the findings of this study suggest that bats may play an integral role in the ecology and evolution of coronaviruses. |
| WOS关键词 | ACUTE-RESPIRATORY-SYNDROME ; INFECTIOUS-BRONCHITIS VIRUS ; SARS-CORONAVIRUS ; MURINE CORONAVIRUSES ; SEQUENCE ALIGNMENT ; GENOME SEQUENCE ; IDENTIFICATION ; PROTEIN ; HOST ; RECOMBINATION |
| WOS研究方向 | Virology |
| WOS类目 | Virology |
| 语种 | 英语 |
| WOS记录号 | WOS:000239189100020 |
| 出版者 | AMER SOC MICROBIOLOGY |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379304 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, H. |
| 作者单位 | 1.Univ Hong Kong, State Key Lab Emerging Infect Dis, Dept Microbiol, Hong Kong, Hong Kong, Peoples R China 2.Chinese Acad Sci, Inst Zool, Beijing 100080, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 4.Guangxi Ctr Dis Control & Prevent, Nanning 530021, Peoples R China 5.Guangxi Med Univ, Dept Microbiol & Immunol, Nanning 530021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, X. C.,Zhang, J. X.,Zhang, S. Y.,et al. Prevalence and genetic diversity of coronaviruses in bats from china[J]. Journal of virology,2006,80(15):7481-7490. |
| APA | Tang, X. C..,Zhang, J. X..,Zhang, S. Y..,Wang, P..,Fan, X. H..,...&Guan, Y..(2006).Prevalence and genetic diversity of coronaviruses in bats from china.Journal of virology,80(15),7481-7490. |
| MLA | Tang, X. C.,et al."Prevalence and genetic diversity of coronaviruses in bats from china".Journal of virology 80.15(2006):7481-7490. |
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来源：中国科学院大学
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