Paradoxical effects of very low dose mk-801
文献类型：期刊论文
| 作者 | Tang, YJ; Zou, H; Strong, JA; Cui, YW; Xie, QP; Zhao, GP; Jin, ML; Yu, L |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 2006-05-10 |
| 卷号 | 537期号:1-3页码:77-84 |
| ISSN号 | 0014-2999 |
| 关键词 | Dizocilpine maleate Nmda receptor antagonist Locomotion Immobility Catalepsy Haloperidol |
| DOI | 10.1016/j.ejphar.2006.03.016 |
| 通讯作者 | Jin, ml() |
| 英文摘要 | Systemic injection of the noncompetitive nmda (n-methyl-d-aspartate) receptor antagonist mk-801 (dizocilpine maleate) is known to cause increased locomotion and various stereotypic behaviors in rodents. however, the mk-801 dose ranges commonly examined usually begin at tenth of mg/kg and going higher, with the implicit assumption of lower doses being ineffective. we report here that very low dose mk-801, well below the commonly studied doses, exert distinct effects on rodent behaviors. in c57bl/6 mice, very low dose mk-801 (0.02 mg/kg) has strikingly different effects than higher doses commonly reported in the literature. locomotion, rearing, grooming, and other behaviors are strongly inhibited, replaced by periods of immobility. this is in contrast to the mobility-enhancing effect of mk-801 at commonly reported dose ranges. the effects of very low dose mk-801 are qualitatively similar to those observed with moderate doses (0.1-0.2 mg/kg) of the typical antipsychotic, haloperidol. these results highlight the complexity of the dose-response relation for mk-801-induced behaviors. (c) 2006 published by elsevier b.v. |
| WOS关键词 | METHYL-D-ASPARTATE ; RECEPTOR SUBTYPES ; BASAL GANGLIA ; SCHIZOPHRENIA ; GLUTAMATE ; MICE ; PHARMACOLOGY ; INVOLVEMENT ; STEREOTYPY ; CATALEPSY |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER SCIENCE BV |
| WOS记录号 | WOS:000237889000012 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379397 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Jin, ML |
| 作者单位 | 1.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai Res Ctr Biotechnol, Shanghai 200233, Peoples R China 2.Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH 45267 USA 3.Rutgers State Univ, Dept Genet, Piscataway, NJ 08854 USA 4.Rutgers State Univ, Ctr Alcohol Studies, Piscataway, NJ 08854 USA |
| 推荐引用方式 GB/T 7714 | Tang, YJ,Zou, H,Strong, JA,et al. Paradoxical effects of very low dose mk-801[J]. European journal of pharmacology,2006,537(1-3):77-84. |
| APA | Tang, YJ.,Zou, H.,Strong, JA.,Cui, YW.,Xie, QP.,...&Yu, L.(2006).Paradoxical effects of very low dose mk-801.European journal of pharmacology,537(1-3),77-84. |
| MLA | Tang, YJ,et al."Paradoxical effects of very low dose mk-801".European journal of pharmacology 537.1-3(2006):77-84. |
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来源：中国科学院大学
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