Synthesis of poly(epsilon-caprolactone)/poly(ethylene glycol) block copolymers and surface property control of their microspheres
文献类型：期刊论文
| 作者 | Yu Guoqiang; Shi Xudong; Gan Zhihua |
| 刊名 | Acta polymerica sinica
 |
| 出版日期 | 2006-08-01 |
| 期号 | 5页码:740-744 |
| 关键词 | Biodegradable polymers Functional amino end-group Microspheres Surface properties |
| ISSN号 | 1000-3304 |
| 通讯作者 | Yu guoqiang() |
| 英文摘要 | A method was developed to synthesize amphiphilic poly(epsilon-caprolactone)-b-poly(ethylene glycol) (pcl-b-peo) block copolymers with well-defined structure and with functional amino end-group connected to the peo block. the molecular weight, composition and chain structure of the resultant copolymers were characterized by gpc and h-1-nmr. the microspheres of the copolymers were prepared by w/o/w double emulsion solvent evaporation method. the analysis results by confocal laser scanning microscopy indicate that the amino groups are distributed dominantly on the surface of microspheres due to the hydrophilic property of amino groups and the formation process of microspheres in aqueous phase. the surface morphology of microspheres could be regulated by changing the composition of block copolymers. the results of this work indicate that the surface properties of the microspheres can be controlled by polymer chain structure,and that the microspheres with amino group located on the surface can be further conjugated with peptide such as rgd. therefore, these microspheres are promising materials as microcarriers for promoting cell growth. |
| WOS关键词 | POLY(ETHYLENE OXIDE) ; RGD-PEPTIDE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000240320600019 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379496 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yu Guoqiang |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu Guoqiang,Shi Xudong,Gan Zhihua. Synthesis of poly(epsilon-caprolactone)/poly(ethylene glycol) block copolymers and surface property control of their microspheres[J]. Acta polymerica sinica,2006(5):740-744. |
| APA | Yu Guoqiang,Shi Xudong,&Gan Zhihua.(2006).Synthesis of poly(epsilon-caprolactone)/poly(ethylene glycol) block copolymers and surface property control of their microspheres.Acta polymerica sinica(5),740-744. |
| MLA | Yu Guoqiang,et al."Synthesis of poly(epsilon-caprolactone)/poly(ethylene glycol) block copolymers and surface property control of their microspheres".Acta polymerica sinica .5(2006):740-744. |
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来源：中国科学院大学
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