中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l.

文献类型:期刊论文

作者Han, JL; Liu, BY; Ye, HC; Wang, H; Li, ZQ; Li, GF
刊名Journal of integrative plant biology
出版日期2006-04-01
卷号48期号:4页码:482-487
关键词Artemisia annua Artemisinin Artemisinin content Farnesyl diphosphate synthase Overexpression
ISSN号1672-9072
通讯作者Ye, hc()
英文摘要Artemisinin is a novel effective antimalarial drug extracted from the medicinal plant artemisia annua l. owing to the tight market and low yield of artemisinin, there is great interest in enhancing the production of artemisinin. in the present study, farnesyl diphosphate synthase (fps) was overexpressed in high-yield a. annua to increase the artemisinin content. the fps activity in transgenic a. annua was two- to threefold greater than that in non-transgenic a. annua. the highest artemisinin content in transgenic a. annua was approximately 0.9% (dry weight), which was 34.4% higher than that in non-transgenic a. annua. the results demonstrate the regulatory role of fps in artemisinin biosynthesis.
WOS关键词SESQUITERPENE CYCLASE ; ANTIMALARIAL-DRUG ; GENE-EXPRESSION ; TRANSFORMATION ; BIOSYNTHESIS ; PLANTS
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
WOS类目Biochemistry & Molecular Biology ; Plant Sciences
语种英语
WOS记录号WOS:000236549200017
出版者BLACKWELL PUBLISHING
URI标识http://www.irgrid.ac.cn/handle/1471x/2379507
专题中国科学院大学
通讯作者Ye, HC
作者单位1.Chinese Acad Sci, Inst Bot, Key Lab Photosynth & Environm Mol Physiol, Beijing 100093, Peoples R China
2.Grad Univ, Chinese Acad Sci, Beijing 100039, Peoples R China
3.Hebei Univ, Coll Life Sci, Hebei 071002, Peoples R China
推荐引用方式
GB/T 7714
Han, JL,Liu, BY,Ye, HC,et al. Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l.[J]. Journal of integrative plant biology,2006,48(4):482-487.
APA Han, JL,Liu, BY,Ye, HC,Wang, H,Li, ZQ,&Li, GF.(2006).Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l..Journal of integrative plant biology,48(4),482-487.
MLA Han, JL,et al."Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l.".Journal of integrative plant biology 48.4(2006):482-487.

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来源:中国科学院大学

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