Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l.
文献类型：期刊论文
| 作者 | Han, JL; Liu, BY; Ye, HC; Wang, H; Li, ZQ; Li, GF |
| 刊名 | Journal of integrative plant biology
 |
| 出版日期 | 2006-04-01 |
| 卷号 | 48期号:4页码:482-487 |
| 关键词 | Artemisia annua Artemisinin Artemisinin content Farnesyl diphosphate synthase Overexpression |
| ISSN号 | 1672-9072 |
| 通讯作者 | Ye, hc() |
| 英文摘要 | Artemisinin is a novel effective antimalarial drug extracted from the medicinal plant artemisia annua l. owing to the tight market and low yield of artemisinin, there is great interest in enhancing the production of artemisinin. in the present study, farnesyl diphosphate synthase (fps) was overexpressed in high-yield a. annua to increase the artemisinin content. the fps activity in transgenic a. annua was two- to threefold greater than that in non-transgenic a. annua. the highest artemisinin content in transgenic a. annua was approximately 0.9% (dry weight), which was 34.4% higher than that in non-transgenic a. annua. the results demonstrate the regulatory role of fps in artemisinin biosynthesis. |
| WOS关键词 | SESQUITERPENE CYCLASE ; ANTIMALARIAL-DRUG ; GENE-EXPRESSION ; TRANSFORMATION ; BIOSYNTHESIS ; PLANTS |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| WOS类目 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000236549200017 |
| 出版者 | BLACKWELL PUBLISHING |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379507 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ye, HC |
| 作者单位 | 1.Chinese Acad Sci, Inst Bot, Key Lab Photosynth & Environm Mol Physiol, Beijing 100093, Peoples R China 2.Grad Univ, Chinese Acad Sci, Beijing 100039, Peoples R China 3.Hebei Univ, Coll Life Sci, Hebei 071002, Peoples R China |
| 推荐引用方式 GB/T 7714 | Han, JL,Liu, BY,Ye, HC,et al. Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l.[J]. Journal of integrative plant biology,2006,48(4):482-487. |
| APA | Han, JL,Liu, BY,Ye, HC,Wang, H,Li, ZQ,&Li, GF.(2006).Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l..Journal of integrative plant biology,48(4),482-487. |
| MLA | Han, JL,et al."Effects of overexpression of the endogenous farnesyl diphosphate synthase on the artemisinin content in artemisia annua l.".Journal of integrative plant biology 48.4(2006):482-487. |
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来源：中国科学院大学
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