Rat pain-related responses induced by experimental scorpion bmk sting
文献类型：期刊论文
| 作者 | Bai, Zhan-Tao; Liu, Tong; Chai, Zhi-Fang; Pang, Xue-Yan; Ji, Yong-Hua |
| 刊名 | European journal of pharmacology
 |
| 出版日期 | 2006-12-15 |
| 卷号 | 552期号:1-3页码:67-77 |
| 关键词 | Scorpion bmk venom Paw inflammation Spontaneous pain Thermal hypersensitivity Mechanical hypersensitivity |
| ISSN号 | 0014-2999 |
| DOI | 10.1016/j.ejphar.2006.09.018 |
| 通讯作者 | Ji, yong-hua(yhji@staff.shu.edu.cn) |
| 英文摘要 | The developmental and pharmacological characteristics of pain responses induced by the experimental scorpion bmk (buthus martensi karsch) sting were detailed in this study. following the unilateral intraplantar injection of bmk venom into rat hind paw, it was found: 1) bmk venom induced an edematogenic response, spontaneous pain and pain hypersensitivity in a dose-dependent manner; 2) the paw edema and flare were induced rapidly and restricted at the injected paw for about 24-48 h; 3) the monophasic tonic spontaneous pain manifested as continuous paw flinching and lifting/licking of the injected paw and lasted for more than 2 h; 4) the detectable thermal hypersensitivity to radiant heat stimuli was just at the injected side for about 72-96 h; 5) the mechanical hypersensitivity to von frey filaments was evoked surprisingly to be the bilateral and mirror-like for about 2-3 weeks; 6) morphine, indomethacin and bupivacaine could suppress bmk venom-induced pain responses with different intensity and time courses. the results indicated that the experimental bmk sting could evoke the prolonged paw inflammation, tonic spontaneous behaviors, unilateral thermal and bilateral mechanical hypersensitivity. the distinct time development of pain responses induced by experimental bmk sting might be involved in different nervous and/or tissue mechanisms. the experimental bmk sting test thus may be an available tissue injury-induced tonic inflammatory pain model for understanding the mechanisms underlying clinical spontaneous pain, thermal and mirror-imaged bilateral mechanical pain hypersensitivity. (c) 2006 elsevier b.v. all rights reserved. |
| WOS关键词 | BUTHUS-MARTENSI KARSCH ; GATED NA+ CURRENTS ; PRIMARY AFFERENT NEURONS ; ROOT GANGLION NEURONS ; C-FOS EXPRESSION ; SPINAL-CORD ; POSSIBLE MECHANISM ; FORMALIN TEST ; INTRAPLANTAR INJECTION ; ACTIVE POLYPEPTIDE |
| WOS研究方向 | Pharmacology & Pharmacy |
| WOS类目 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000242452500009 |
| 出版者 | ELSEVIER SCIENCE BV |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379565 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Physiol, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Bai, Zhan-Tao,Liu, Tong,Chai, Zhi-Fang,et al. Rat pain-related responses induced by experimental scorpion bmk sting[J]. European journal of pharmacology,2006,552(1-3):67-77. |
| APA | Bai, Zhan-Tao,Liu, Tong,Chai, Zhi-Fang,Pang, Xue-Yan,&Ji, Yong-Hua.(2006).Rat pain-related responses induced by experimental scorpion bmk sting.European journal of pharmacology,552(1-3),67-77. |
| MLA | Bai, Zhan-Tao,et al."Rat pain-related responses induced by experimental scorpion bmk sting".European journal of pharmacology 552.1-3(2006):67-77. |
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来源：中国科学院大学
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