Dynamic changes in subgraph preference profiles of crucial transcription factors
文献类型：期刊论文
| 作者 | Zhang, Zhihua; Liu, Changning; Skogerbo, Geir; Zhu, Xiaopeng; Lu, Hongchao; Chen, Lan; Shi, Baochen; Zhang, Yong; Wang, Jie; Wu, Tao |
| 刊名 | Plos computational biology
 |
| 出版日期 | 2006-05-01 |
| 卷号 | 2期号:5页码:383-391 |
| ISSN号 | 1553-734X |
| DOI | 10.1371/journal.pcbi.0020047 |
| 通讯作者 | Chen, runsheng(crs@sun5.ibp.ac.cn) |
| 英文摘要 | Transcription factors with a large number of target genes - transcription hub( s), or thub( s) - are usually crucial components of the regulatory system of a cell, and the different patterns through which they transfer the transcriptional signal to downstream cascades are of great interest. by profiling normalized abundances ( an) of basic regulatory patterns of individual thubs in the yeast saccharomyces cerevisiae transcriptional regulation network under five different cellular states and environmental conditions, we have investigated their preferences for different basic regulatory patterns. subgraph-normalized abundances downstream of individual thubs often differ significantly from that of the network as a whole, and conversely, certain over-represented subgraphs are not preferred by any thub. the thub preferences changed substantially when the cellular or environmental conditions changed. this switching of regulatory pattern preferences suggests that a change in conditions does not only elicit a change in response by the regulatory network, but also a change in the mechanisms by which the response is mediated. the thub subgraph preference profile thus provides a novel tool for description of the structure and organization between the large- scale exponents and local regulatory patterns. |
| WOS关键词 | REGULATORY NETWORK ; ESCHERICHIA-COLI ; SACCHAROMYCES-CEREVISIAE ; HIERARCHICAL STRUCTURE ; COMPLEX NETWORKS ; GENOMIC ANALYSIS ; GENE ; MOTIFS ; PROTEIN ; ACTIVATION |
| WOS研究方向 | Biochemistry & Molecular Biology ; Mathematical & Computational Biology |
| WOS类目 | Biochemical Research Methods ; Mathematical & Computational Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000239493900007 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379641 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Runsheng |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, Bioinformat Lab, Beijing, Peoples R China 2.Chinese Acad Sci, Natl Lab Biomacromol, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Comp Technol, Key Lab Intelligent Informat Proc, Bioinformat Res Grp, Beijing, Peoples R China 4.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Zhihua,Liu, Changning,Skogerbo, Geir,et al. Dynamic changes in subgraph preference profiles of crucial transcription factors[J]. Plos computational biology,2006,2(5):383-391. |
| APA | Zhang, Zhihua.,Liu, Changning.,Skogerbo, Geir.,Zhu, Xiaopeng.,Lu, Hongchao.,...&Chen, Runsheng.(2006).Dynamic changes in subgraph preference profiles of crucial transcription factors.Plos computational biology,2(5),383-391. |
| MLA | Zhang, Zhihua,et al."Dynamic changes in subgraph preference profiles of crucial transcription factors".Plos computational biology 2.5(2006):383-391. |
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来源：中国科学院大学
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