Effects of il-1 beta on rt1-a/rt1-dm at the maternal-fetal interface during pregnancy in rats
文献类型：期刊论文
| 作者 | Xia, HF; Peng, JP; Sun, QH; Yang, Y; Liu, ML |
| 刊名 | Frontiers in bioscience
 |
| 出版日期 | 2006-09-01 |
| 卷号 | 11页码:2867-2875 |
| 关键词 | Interleukin-1 beta Rt1-a Rt1-dm Uterus Placenta |
| ISSN号 | 1093-9946 |
| 通讯作者 | Peng, jp() |
| 英文摘要 | Interleukin-1 (il-1beta) beta and major histocompatibility complex (mhc) play an important role during pregnancy. expression of non-classical class mhc ii rt1-dm antigen and classical class mhc i rt1-a antigen induced by il-1beta was examined by northern blotting, western blotting and immunohistochemistry. il-1beta treatment significantly increased the expression of rt1-a and rt1-dm in early and mid pregnancy. in late pregnancy, expression of rt1-dm significantly increased in uteri and decreased in placenta. immunohistochemical studies indicated that, in early pregnancy, rt1-dm protein mainly localized to luminal and glandular uterine epithelium, and rt1-a was present in deciduas basalis, outer layer of luminal epithelium and glandular epithelium. during mid and late pregnancy, rt1-dm was present in maternal blood vessels and syncytio-trophoblast of labyrinthine zone, and rt1-a was present in maternal blood vessels and trophoblastic epithelium of the labyrinthine layers. these findings show that exogenous il-1beta affects expression of rt1-dm and rt1-a and does not affect the localization of corresponding molecules during pregnancy. |
| WOS关键词 | TUMOR-NECROSIS-FACTOR ; MHC CLASS-I ; IFN-GAMMA ; HLA-DM ; INTERFERON-GAMMA ; EXPRESSION ; MOLECULES ; INTERLEUKIN-6 ; TRANSCRIPTION ; ANTIGEN |
| WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
| WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000237382800074 |
| 出版者 | FRONTIERS IN BIOSCIENCE INC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379646 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Peng, JP |
| 作者单位 | Grad Univ, Chinese Acad Sci, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, HF,Peng, JP,Sun, QH,et al. Effects of il-1 beta on rt1-a/rt1-dm at the maternal-fetal interface during pregnancy in rats[J]. Frontiers in bioscience,2006,11:2867-2875. |
| APA | Xia, HF,Peng, JP,Sun, QH,Yang, Y,&Liu, ML.(2006).Effects of il-1 beta on rt1-a/rt1-dm at the maternal-fetal interface during pregnancy in rats.Frontiers in bioscience,11,2867-2875. |
| MLA | Xia, HF,et al."Effects of il-1 beta on rt1-a/rt1-dm at the maternal-fetal interface during pregnancy in rats".Frontiers in bioscience 11(2006):2867-2875. |
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来源：中国科学院大学
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