Streptococcal toxic shock syndrome caused by streptococcus suis serotype 2
文献类型：期刊论文
| 作者 | Tang, Jiaqi; Wang, Changjun; Feng, Youjun; Yang, Weizhong; Song, Huaidong; Chen, Zhihai; Yu, Hongjie; Pan, Xiuzhen; Zhou, Xiaojun; Wang, Huaru |
| 刊名 | Plos medicine
 |
| 出版日期 | 2006-05-01 |
| 卷号 | 3期号:5页码:668-676 |
| ISSN号 | 1549-1277 |
| DOI | 10.1371/journal.pmed.0030151 |
| 通讯作者 | Tang, jiaqi(tjq85@hotmail.com) |
| 英文摘要 | Background streptococcus suis serotype 2 (s. suis 2, ss2) is a major zoonotic pathogen that causes only sporadic cases of meningitis and sepsis in humans. most if not all cases of streptococcal toxic shock-syndrome (stss) that have been well-documented to date were associated with the non-ss2 group a streptococcus (gas). however, a recent large-scale outbreak of ss2 in sichuan province, china, appeared to be caused by more invasive deep-tissue infection with stss, characterized by acute high fever, vascular collapse, hypotension, shock, and multiple organ failure. methods and findings we investigated this outbreak of ss2 infections in both human and pigs, which took place from july to august, 2005, through clinical observation and laboratory experiments. clinical and pathological characterization of the human patients revealed the hallmarks of typical stss, which to date had only been associated with gas infection. retrospectively, we found that this outbreak was very similar to an earlier outbreak in jiangsu province, china, in 1998. we isolated and analyzed 37 bacterial strains from human specimens and eight from pig specimens of the as well as three human isolates and two pig isolates from the 1998 outbreak recent outbreak, we had kept in our laboratory. the bacterial isolates were examined using light microscopy observation, pig infection experiments, multiplex-pcr assay, as well as restriction fragment length polymorphisms (rflp) and multiple sequence alignment analyses. multiple lines of evidence confirmed that highly virulent strains of ss2 were the causative agents of both outbreaks. conclusions we report to our knowledge for the first time, two outbreaks of stss caused by ss2, a non-gas streptococcus. the 2005 outbreak was associated with 38 deaths out of 204 documented human cases; the 1998 outbreak with 14 deaths out of 25 reported human cases. most of the fatal cases were characterized by stss; some of them by meningitis or severe septicemia. the molecular mechanisms underlying these human stss outbreaks in human beings remain unclear and an objective for further study. |
| WOS关键词 | INVASIVE GROUP-A ; GLUTAMATE-DEHYDROGENASE ; PCR ASSAYS ; GROUP-C ; STRAINS ; VIRULENCE ; PATHOGENESIS ; SUILYSIN ; PROTEIN ; TYPE-2 |
| WOS研究方向 | General & Internal Medicine |
| WOS类目 | Medicine, General & Internal |
| 语种 | 英语 |
| WOS记录号 | WOS:000238623900022 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379658 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Jiaqi |
| 作者单位 | 1.Res Inst Med NanjingCommand, Dept Epidemiol, Nanjing, Peoples R China 2.Chinese Acad Sci, Inst Microbiol, State Key Lab Microbial Resources, Beijing, Peoples R China 3.Chinese Acad Sci, Ctr Mol Immunol, Beijing, Peoples R China 4.Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China 5.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, State Key Lab Med Genom, Shanghai 200030, Peoples R China 6.Beijing Ditan Hosp, Beijing, Peoples R China 7.Jinling Hosp, Dept Pathol, Nanjing, Peoples R China 8.S China Univ Technol, Sch Biosci & Bioengn, Guangzhou, Peoples R China 9.Chinese Acad Sci, Beijing Genom Inst, Beijing, Peoples R China 10.Chinese Natl Human Genome Ctr, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Jiaqi,Wang, Changjun,Feng, Youjun,et al. Streptococcal toxic shock syndrome caused by streptococcus suis serotype 2[J]. Plos medicine,2006,3(5):668-676. |
| APA | Tang, Jiaqi.,Wang, Changjun.,Feng, Youjun.,Yang, Weizhong.,Song, Huaidong.,...&Gao, George F..(2006).Streptococcal toxic shock syndrome caused by streptococcus suis serotype 2.Plos medicine,3(5),668-676. |
| MLA | Tang, Jiaqi,et al."Streptococcal toxic shock syndrome caused by streptococcus suis serotype 2".Plos medicine 3.5(2006):668-676. |
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来源：中国科学院大学
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