Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin
文献类型:期刊论文
作者 | Wang, Y; Zhang, SY; Ma, XF; Tian, WX |
刊名 | Journal of enzyme inhibition and medicinal chemistry
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出版日期 | 2006-02-01 |
卷号 | 21期号:1页码:87-93 |
关键词 | Fatty acid synthase Inhibition Kinetics Parasitic loranthus (taxillus chinensis) Avicularin |
ISSN号 | 1475-6366 |
DOI | 10.1080/14756360500472829 |
通讯作者 | Tian, wx() |
英文摘要 | The medicinal herb parasitic loranthus in a screen was found to inhibit fatty acid synthase (ec 2.3.1.85, fas) and reduce body weight of rats in our previous study. now we have determined the inhibitory characteristics and kinetic parameters of extracts of parasitic loranthus [taxillus chinensis (dc.) danser]. the parasitic loranthus extracts (ple) inhibits fas reversibly and irreversibly and with an ic50 value of 0.48 mu g/ml, appears to be the most potent inhibitor reported to date. ple contains various potent inhibitors and may react with different sites on fas. the irreversible inhibition exhibits a time-dependent biphasic process including a speedy fast-phase during the initial several minutes. the fast-phase inhibition seems to be caused by some potent but low-concentration component(s) in the extracts. in addition, we have found that avicularin existing in this herb can potently inhibit fas. this glycosylated flavonoid and quercetin play an effective role in inhibiting fas by parasitic loranthus. |
WOS关键词 | FOOD-INTAKE ; SYNTHETASE ; CERULENIN ; WEIGHT ; ENZYME |
WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
语种 | 英语 |
WOS记录号 | WOS:000236146500013 |
出版者 | TAYLOR & FRANCIS LTD |
URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379688 |
专题 | 中国科学院大学 |
通讯作者 | Tian, WX |
作者单位 | Grad Univ, Chinese Acad Sci, Dept Biol, Beijing 100049, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Y,Zhang, SY,Ma, XF,et al. Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin[J]. Journal of enzyme inhibition and medicinal chemistry,2006,21(1):87-93. |
APA | Wang, Y,Zhang, SY,Ma, XF,&Tian, WX.(2006).Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin.Journal of enzyme inhibition and medicinal chemistry,21(1),87-93. |
MLA | Wang, Y,et al."Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin".Journal of enzyme inhibition and medicinal chemistry 21.1(2006):87-93. |
入库方式: iSwitch采集
来源:中国科学院大学
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