中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin

文献类型:期刊论文

作者Wang, Y; Zhang, SY; Ma, XF; Tian, WX
刊名Journal of enzyme inhibition and medicinal chemistry
出版日期2006-02-01
卷号21期号:1页码:87-93
关键词Fatty acid synthase Inhibition Kinetics Parasitic loranthus (taxillus chinensis) Avicularin
ISSN号1475-6366
DOI10.1080/14756360500472829
通讯作者Tian, wx()
英文摘要The medicinal herb parasitic loranthus in a screen was found to inhibit fatty acid synthase (ec 2.3.1.85, fas) and reduce body weight of rats in our previous study. now we have determined the inhibitory characteristics and kinetic parameters of extracts of parasitic loranthus [taxillus chinensis (dc.) danser]. the parasitic loranthus extracts (ple) inhibits fas reversibly and irreversibly and with an ic50 value of 0.48 mu g/ml, appears to be the most potent inhibitor reported to date. ple contains various potent inhibitors and may react with different sites on fas. the irreversible inhibition exhibits a time-dependent biphasic process including a speedy fast-phase during the initial several minutes. the fast-phase inhibition seems to be caused by some potent but low-concentration component(s) in the extracts. in addition, we have found that avicularin existing in this herb can potently inhibit fas. this glycosylated flavonoid and quercetin play an effective role in inhibiting fas by parasitic loranthus.
WOS关键词FOOD-INTAKE ; SYNTHETASE ; CERULENIN ; WEIGHT ; ENZYME
WOS研究方向Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
WOS类目Biochemistry & Molecular Biology ; Chemistry, Medicinal
语种英语
WOS记录号WOS:000236146500013
出版者TAYLOR & FRANCIS LTD
URI标识http://www.irgrid.ac.cn/handle/1471x/2379688
专题中国科学院大学
通讯作者Tian, WX
作者单位Grad Univ, Chinese Acad Sci, Dept Biol, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714
Wang, Y,Zhang, SY,Ma, XF,et al. Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin[J]. Journal of enzyme inhibition and medicinal chemistry,2006,21(1):87-93.
APA Wang, Y,Zhang, SY,Ma, XF,&Tian, WX.(2006).Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin.Journal of enzyme inhibition and medicinal chemistry,21(1),87-93.
MLA Wang, Y,et al."Potent inhibition of fatty acid synthase by parasitic loranthus [taxillus chinensis (dc.) danser] and its constituent avicularin".Journal of enzyme inhibition and medicinal chemistry 21.1(2006):87-93.

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来源:中国科学院大学

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