Off response of bullfrog cones is shaped by terminal ionotropic gaba receptors
文献类型：期刊论文
| 作者 | Liu, Jian; Yang, Xiong-Li |
| 刊名 | Brain research bulletin
 |
| 出版日期 | 2006-12-11 |
| 卷号 | 71期号:1-3页码:219-223 |
| 关键词 | Retina Chloride channel Bicuculline Light response Membrane potential Equilibrium potential |
| ISSN号 | 0361-9230 |
| DOI | 10.1016/j.brainresbull.2006.09.006 |
| 通讯作者 | Yang, xiong-li(xlyang@fudan.edu.cn) |
| 英文摘要 | We recently reported an ionotropic gaba receptor expressed at the bullfrog retinal cone terminal that is potentiated by the gaba(a) receptor antagonist bicuculline (bic) and suppressed by the gaba(c) receptor antagonist imidazole-4-acetic acid (i4aa) [13]. in this study, by using the patch clamp technique in current clamp mode, we show that activation of this gaba receptor causes voltage changes of cones, which are closely dependent on the membrane potential level in relation to the chloride equilibrium potential of the cells. furthermore, the off overshoot of cone light responses is enhanced or diminished when this receptor is potentiated by bic or suppressed by i4aa, suggesting the involvement of this gaba receptor in shaping off light responses of bullfrog cones. (c) 2006 elsevier inc. all rights reserved. |
| WOS关键词 | HORIZONTAL CELLS ; PHOTORECEPTOR TERMINALS ; TURTLE RETINA ; BIPOLAR CELL ; FEEDBACK ; INHIBITION ; SYNAPSE ; SALAMANDER ; CHANNELS ; GOLDFISH |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000242735500030 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379776 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yang, Xiong-Li |
| 作者单位 | 1.Fudan Univ, Inst Neurobiol, Inst Brain Sci, Shanghai 200031, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Jian,Yang, Xiong-Li. Off response of bullfrog cones is shaped by terminal ionotropic gaba receptors[J]. Brain research bulletin,2006,71(1-3):219-223. |
| APA | Liu, Jian,&Yang, Xiong-Li.(2006).Off response of bullfrog cones is shaped by terminal ionotropic gaba receptors.Brain research bulletin,71(1-3),219-223. |
| MLA | Liu, Jian,et al."Off response of bullfrog cones is shaped by terminal ionotropic gaba receptors".Brain research bulletin 71.1-3(2006):219-223. |
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来源：中国科学院大学
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