Angiopoietin-related growth factor (agf) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with rgd-binding integrins
文献类型：期刊论文
| 作者 | Zhang, Yueqing; Hu, Xiaobo; Tian, Ruiyang; Wei, Wangui; Hu, Wei; Chen, Xia; Han, Wei; Chen, Huayou; Gong, Yi |
| 刊名 | Biochemical and biophysical research communications
 |
| 出版日期 | 2006-08-18 |
| 卷号 | 347期号:1页码:100-108 |
| 关键词 | Angiopoietin-related growth factor Rgd-binding integrins Keratinocyte Fibroblast Endotbelial cell Cell proliferation Cell adhesion Cell spreading Cell migration |
| ISSN号 | 0006-291X |
| DOI | 10.1016/j.bbrc.2006.06.053 |
| 通讯作者 | Gong, yi(ygong@sibs.ac.cn) |
| 英文摘要 | Angiopoietin-related growth factor (agf) is a newly identified member of angiopoietin-related proteins (arps)/angiopoietin-like proteins (angptls). agf has been considered as a novel growth factor in accelerating cutaneous wound healing, as it is capable of stimulating keratinocytes proliferation as well as angiogenesis. but in our paper, we demonstrate that agf stimulates keratinocytes proliferation only at high protein concentration, however, it can potently promote adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells. furthermore, we confirm that the adhesion and migration cellular events are mediated by rgd-binding integrins, most possibly the alpha(v)-containing integrins, by in vitro inhibition assays using synthetic competitive peptides. our results strongly suggest that agf is an integrin ligand as well as a mitogenic growth factor and theoretically participates in cutaneous wound healing in a more complex mechanism. (c) 2006 elsevier inc. all rights reserved. |
| WOS关键词 | PROMOTES ANGIOGENESIS ; ALPHA(V)BETA(3) ; ALPHA-V-BETA-3 ; FIBRONECTIN ; MECHANISMS ; ALPHA-5-BETA-1 ; PROLIFERATION ; LOCALIZATION ; SPECIFICITY ; PEPTIDES |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics |
| WOS类目 | Biochemistry & Molecular Biology ; Biophysics |
| 语种 | 英语 |
| WOS记录号 | WOS:000239198000014 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379803 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Gong, Yi |
| 作者单位 | Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Shanghai 200233, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Yueqing,Hu, Xiaobo,Tian, Ruiyang,et al. Angiopoietin-related growth factor (agf) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with rgd-binding integrins[J]. Biochemical and biophysical research communications,2006,347(1):100-108. |
| APA | Zhang, Yueqing.,Hu, Xiaobo.,Tian, Ruiyang.,Wei, Wangui.,Hu, Wei.,...&Gong, Yi.(2006).Angiopoietin-related growth factor (agf) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with rgd-binding integrins.Biochemical and biophysical research communications,347(1),100-108. |
| MLA | Zhang, Yueqing,et al."Angiopoietin-related growth factor (agf) supports adhesion, spreading, and migration of keratinocytes, fibroblasts, and endothelial cells through interaction with rgd-binding integrins".Biochemical and biophysical research communications 347.1(2006):100-108. |
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来源：中国科学院大学
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