Expression of qbrn-1, a new member of the pou gene family, in the early developing nervous system and embryonic kidney
文献类型：期刊论文
| 作者 | Lan, L; Liu, MN; Liu, Y; Liu, Y; Zhang, W; Xue, JX; Xue, ZG; He, RQ |
| 刊名 | Developmental dynamics
 |
| 出版日期 | 2006-04-01 |
| 卷号 | 235期号:4页码:1107-1114 |
| 关键词 | Qbrn-1 Qbrn-2 Quail Development Nervous system Kidney Neural crests Notochord Auditory pits Branchial arches |
| ISSN号 | 1058-8388 |
| DOI | 10.1002/dvdy.20703 |
| 通讯作者 | He, rq() |
| 英文摘要 | It has been shown that pou domain genes play critical roles in the development of the nervous system. we have obtained a new member of the class iii pou domain genes, qbrn-1, from the cdna library of embryonic day 5 quail and have made an extensive expression pattern analysis of qbrn-1 and qbrn-2 throughout the early embryonic development by in situ hybridization. with a specific antibody we prepared, further analysis by immunohistochemistry showed that the location of qbrn-1 protein was consistent with that of the transcripts in the early developing quail. our results showed that both qbrn-1 and qbrn-2 were preferentially expressed in the developing central nervous system, and their transcripts were initially detected in the neural plate and later in the distinct regions of the neural tube with a stage-dependent pattern. moreover, their expression was also detected in both notochord and neural crests. however, qbrn-1 signal, different from qbrn-2, was more widely found in the auditory pits, branchial arches, and in the mesodermal components of the developing kidney. and the expression of qbrn-1 in nephric region was earlier and wider than that of mouse brn-1, suggesting the characteristic function of qbrn-1 in the kidney formation. the distinct dynamic expression patterns of qbrn-1 and qbrn-2 indicate multiple roles of the class iii pou genes in quail neurogenesis and organogenesis. |
| WOS关键词 | TRANSCRIPTION FACTORS ; CHICK-EMBRYO ; DOMAIN FACTORS ; CRUCIAL ROLES ; FACTOR BRN-2 ; MOUSE ; HYPOTHALAMUS ; MIGRATION ; QUAIL |
| WOS研究方向 | Anatomy & Morphology ; Developmental Biology |
| WOS类目 | Anatomy & Morphology ; Developmental Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000236444600024 |
| 出版者 | WILEY-LISS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379820 |
| 专题 | 中国科学院大学 |
| 通讯作者 | He, RQ |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing, Peoples R China 3.Univ Paris 07, Paris, France |
| 推荐引用方式 GB/T 7714 | Lan, L,Liu, MN,Liu, Y,et al. Expression of qbrn-1, a new member of the pou gene family, in the early developing nervous system and embryonic kidney[J]. Developmental dynamics,2006,235(4):1107-1114. |
| APA | Lan, L.,Liu, MN.,Liu, Y.,Liu, Y.,Zhang, W.,...&He, RQ.(2006).Expression of qbrn-1, a new member of the pou gene family, in the early developing nervous system and embryonic kidney.Developmental dynamics,235(4),1107-1114. |
| MLA | Lan, L,et al."Expression of qbrn-1, a new member of the pou gene family, in the early developing nervous system and embryonic kidney".Developmental dynamics 235.4(2006):1107-1114. |
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来源：中国科学院大学
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