The extract of leaves of acer truncatum bunge: a natural inhibitor of fatty acid synthase with antitumor activity
文献类型：期刊论文
| 作者 | Zhao, Wen-Hua; Zhang, Jin-Feng; Zhe-Wang; Zhang, Ying-Xia; Tian, Wei-Xi |
| 刊名 | Journal of enzyme inhibition and medicinal chemistry
 |
| 出版日期 | 2006-10-01 |
| 卷号 | 21期号:5页码:589-596 |
| 关键词 | Fatty acid synthase Enzyme inhibition Antitumor Acer truncatum bunge Kinetics |
| ISSN号 | 1475-6366 |
| DOI | 10.1080/14756360600774579 |
| 通讯作者 | Zhang, ying-xia(zhangyue@cpums.edu.cn) |
| 英文摘要 | Fatty acid synthase (fas) has been identified as a potential antitumor target. the extract from the leaves of acer truncatum bunge (extr) was prepared to assay its inhibitory activity against fas, which was isolated from duck liver, and the correlated antitumor bioactivity. its inhibition of fas is composed of reversible fast-binding inhibition, ic50 = 0.7 mu g/ml, and irreversible slow-binding inhibition following saturation kinetics with a dissociation constant of 0.68 mu g/ml and a limiting rate constant of 0.0288 min(-1). the extr exhibited different type of inhibitions against the three substrates in the fas overall reaction. compared with egcg in inhibition constant and ic50 value, the extr appeared to be a more efficient inhibitor, and exhibited a considerable inhibition against the growth of four kinds of cancer cells ( patent application number 200510068054.2). it was infered that the inhibitory activity is likely attributable to the co-operative effect of the components. |
| WOS关键词 | BREAST-CANCER CELLS ; PROSTATE-CANCER ; EPIGALLOCATECHIN GALLATE ; THERAPEUTIC TARGET ; CHICKEN LIVER ; BODY-WEIGHT ; FOOD-INTAKE ; TEA ; EXPRESSION ; ENZYME |
| WOS研究方向 | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| WOS类目 | Biochemistry & Molecular Biology ; Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000242044300016 |
| 出版者 | TAYLOR & FRANCIS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379826 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Ying-Xia |
| 作者单位 | 1.Capital Univ Med Sci, Dept Chem Biol, Beijing 100069, Peoples R China 2.Capital Univ Med Sci, Dept Cell Biol, Beijing 100069, Peoples R China 3.Capital Univ Med Sci, Lab Liver Protect & Regulat, Beijing 100069, Peoples R China 4.Chinese Acad Sci, Grad Sch, Dept Biol, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Wen-Hua,Zhang, Jin-Feng,Zhe-Wang,et al. The extract of leaves of acer truncatum bunge: a natural inhibitor of fatty acid synthase with antitumor activity[J]. Journal of enzyme inhibition and medicinal chemistry,2006,21(5):589-596. |
| APA | Zhao, Wen-Hua,Zhang, Jin-Feng,Zhe-Wang,Zhang, Ying-Xia,&Tian, Wei-Xi.(2006).The extract of leaves of acer truncatum bunge: a natural inhibitor of fatty acid synthase with antitumor activity.Journal of enzyme inhibition and medicinal chemistry,21(5),589-596. |
| MLA | Zhao, Wen-Hua,et al."The extract of leaves of acer truncatum bunge: a natural inhibitor of fatty acid synthase with antitumor activity".Journal of enzyme inhibition and medicinal chemistry 21.5(2006):589-596. |
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来源：中国科学院大学
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