Comparative analysis of whole-genome sequences of streptococcus suis
文献类型：期刊论文
| 作者 | Wei Wu; Ding Guohui; Wang Xiaojing; Sun Jingchun; Tu Kang; Hao Pei; Wang Chuan; Cao Zhiwei; Shi Tieliu; Li Yixue |
| 刊名 | Chinese science bulletin
 |
| 出版日期 | 2006-05-01 |
| 卷号 | 51期号:10页码:1199-1209 |
| 关键词 | Streptococcus suis Strain p1/7 Strain 89-1591 Virulence factor |
| ISSN号 | 1001-6538 |
| DOI | 10.1007/s11434-006-1199-9 |
| 通讯作者 | Cao zhiwei(zwcao@scbit.org) |
| 英文摘要 | The outbreak of streptococcus suis recently in some districts of sichuan province in china has caused over 30 deaths and over 200 infections in human beings. in order to study the pathogenicity mechanism and to prevent the bacteria from spreading and infecting human beings and swine, we have annotated and analyzed the genomes of two strains, streptococcus suis p1/7 and 89-1591 respectively. the whole length of p1/7 is 2.007 mb, and has 1969 orfs. in contrast, the partial genome sequence of 89-1591 is 1.98 mb in length and exists in 177 contigs with 1918 orfs. analysis shows that the average lengths of cdss in two genomes are very close, and the numbers of the homolog orfs are 1306 between those two strains. most of the toxicity factors of the two strains are homologeous, but there are still some significant differences between those two strains. for example, among the 11 genes (cps2a-cps2k) encoding for the capsules in p1/7, 4 (cps2a, 2b, 2i, 2j) are not detected in strain 89-1591. at the same time, the genes encoding ef and haemolysin in p1/7 are also not found in strain 89-1591. besides, the genes related to dna replication, repair and recombination differ from each other significantly and there also exist certain differences among the surface proteins. those characteristics indicate that those two strains have evolved their own specific functions to adapt to the different environments and that the pathogenesis of the two strains is different. we have accumulated comprehensive genomics information for future systematic studies of s. sui. our results are helpful for disease prevention, vaccine development, as well as drug design for s. suis. |
| WOS关键词 | PROTEIN-PROTEIN INTERACTIONS ; GROUP-A STREPTOCOCCUS ; PHYLOGENETIC PROFILES ; CAPSULAR TYPES ; PSI-BLAST ; VIRULENCE ; IDENTIFICATION ; MENINGITIS ; STRAINS ; TYPE-2 |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000238882200007 |
| 出版者 | SCIENCE CHINA PRESS |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379909 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cao Zhiwei |
| 作者单位 | 1.Shanghai Ctr Bioinformat Technol, Shanghai 200235, Peoples R China 2.Chinese Acad Sci, Grad Sch, Shanghai Inst Biol Sci, Bioinformat Ctr, Shanghai 200031, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei Wu,Ding Guohui,Wang Xiaojing,et al. Comparative analysis of whole-genome sequences of streptococcus suis[J]. Chinese science bulletin,2006,51(10):1199-1209. |
| APA | Wei Wu.,Ding Guohui.,Wang Xiaojing.,Sun Jingchun.,Tu Kang.,...&Li Yixue.(2006).Comparative analysis of whole-genome sequences of streptococcus suis.Chinese science bulletin,51(10),1199-1209. |
| MLA | Wei Wu,et al."Comparative analysis of whole-genome sequences of streptococcus suis".Chinese science bulletin 51.10(2006):1199-1209. |
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来源：中国科学院大学
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