A temperature-responsive copolymer hydrogel in controlled drug delivery
文献类型：期刊论文
| 作者 | Dai, Hongjun; Chen, Qiang; Qin, Huaili; Guan, Ying; Shen, Deyan; Hua, Youqing; Tang, Yalin; Xu, Jian |
| 刊名 | Macromolecules
 |
| 出版日期 | 2006-09-19 |
| 卷号 | 39期号:19页码:6584-6589 |
| ISSN号 | 0024-9297 |
| DOI | 10.1021/ma060486p |
| 通讯作者 | Tang, yalin(tangyl@iccas.ac.cn) |
| 英文摘要 | A novel optical transition for a hydrogel of polyacrylamide and poly( acrylic acid) random copolymer was observed. the poly( acrylamide- co- acrylic acid) hydrogel is opaque white at low temperature, while it will become transparent gradually or sharply on a fast or slow increase of temperature. meanwhile, the hydrogel can swell or collapse with changing temperature. both optical transition and volume swelling are reversible responding to temperature stimuli. the ft- ir, laser raman, and 1h nmr spectroscopy demonstrated the driving force of optical and volume transition: formation and dissociation of hydrogen bonds in the hydrogel. the heterogeneity of the network results in these reversible transition responding to temperature stimuli. the effects of monomer, initiator, and cross- linker on the optical transition of the hydrogel were studied in detail. the formation and dissociation of hydrogen bonds in the limited domain of the hydrogel is related to the network structure. because of the property of swelling or collapse, the p( aam- co- aac) hydrogel has potential value of application in drug controlled release. |
| WOS关键词 | MEMBRANE EMULSIFICATION TECHNIQUE ; POLY(ACRYLIC ACID) ; PHASE-TRANSITION ; INTERPOLYMER COMPLEXES ; COMPLEMENTARY POLYMERS ; SURFACE-PROPERTIES ; GELS ; MICROSPHERES ; ACRYLAMIDE ; RELEASE |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000240437200040 |
| 出版者 | AMER CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379930 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Yalin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China 3.Beijing Univ Chem Technol, Sch Mat Sci & Engn, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dai, Hongjun,Chen, Qiang,Qin, Huaili,et al. A temperature-responsive copolymer hydrogel in controlled drug delivery[J]. Macromolecules,2006,39(19):6584-6589. |
| APA | Dai, Hongjun.,Chen, Qiang.,Qin, Huaili.,Guan, Ying.,Shen, Deyan.,...&Xu, Jian.(2006).A temperature-responsive copolymer hydrogel in controlled drug delivery.Macromolecules,39(19),6584-6589. |
| MLA | Dai, Hongjun,et al."A temperature-responsive copolymer hydrogel in controlled drug delivery".Macromolecules 39.19(2006):6584-6589. |
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来源：中国科学院大学
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