The new convenient synthesis of fluorinated penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (fhbg) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-fluoropenciclovir)
文献类型：期刊论文
| 作者 | Cai, Hancheng; Yin, Duanzhi; Zhang, Lan; Wang, Yongxian |
| 刊名 | Journal of fluorine chemistry
 |
| 出版日期 | 2006-07-01 |
| 卷号 | 127期号:7页码:837-841 |
| 关键词 | Penciclovir Anti-viral agent Pet Fluorination reaction Synthesis |
| ISSN号 | 0022-1139 |
| DOI | 10.1016/j.jfluchem.2006.03.002 |
| 通讯作者 | Yin, duanzhi(chcbati@yahoo.com.cn) |
| 英文摘要 | 9-(4-hydroxy-3-hydroxymethylbutyl) guanine (penciclovir) is a potent and selective inhibitor of members of the herpes virus family. a new convenient synthesis of fluorinated penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (fhbg) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxy-methylbutyl) purine (6-fluoropenciclovir) were described. the structures of the products were characterized by uv, ir, h-1 nmr, f-19 nmr spectra and ms. (c) 2006 elsevier b.v. all rights reserved. |
| WOS关键词 | REPORTER GENE-EXPRESSION ; TYPE-1 THYMIDINE KINASE ; TETRABUTYLAMMONIUM FLUORIDE ; NUCLEOSIDE ANALOGS ; PET ; CHEMISTRY ; THERAPY ; ENZYME ; AGENT ; PROBE |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Inorganic & Nuclear ; Chemistry, Organic |
| 语种 | 英语 |
| WOS记录号 | WOS:000238901300002 |
| 出版者 | ELSEVIER SCIENCE SA |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2379975 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Yin, Duanzhi |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Appl Phys, Res Ctr Radiopharmaceut, Shanghai 201800, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cai, Hancheng,Yin, Duanzhi,Zhang, Lan,et al. The new convenient synthesis of fluorinated penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (fhbg) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-fluoropenciclovir)[J]. Journal of fluorine chemistry,2006,127(7):837-841. |
| APA | Cai, Hancheng,Yin, Duanzhi,Zhang, Lan,&Wang, Yongxian.(2006).The new convenient synthesis of fluorinated penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (fhbg) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-fluoropenciclovir).Journal of fluorine chemistry,127(7),837-841. |
| MLA | Cai, Hancheng,et al."The new convenient synthesis of fluorinated penciclovir analogues 9-(4-fluoro-3-hydroxymethylbutyl) guanine (fhbg) and 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbutyl) purine (6-fluoropenciclovir)".Journal of fluorine chemistry 127.7(2006):837-841. |
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来源：中国科学院大学
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