Electrophysiology of hyperpolarization-activated cyclic nucleotidegated cation channel 2 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 expressed in hek293 cells
文献类型：期刊论文
| 作者 | Li Chun; Guo Ji-hong; Li Ji-wen; Liu Yuan-wei; Hao Xue-mei; Zhang Ping; Wang Shi-qiang |
| 刊名 | Chinese medical journal
 |
| 出版日期 | 2007-11-20 |
| 卷号 | 120期号:22页码:2039-2041 |
| 关键词 | Hyperpolarization-activated cyclic nucleotide-gated potassium channel Hek293 cell Whole cell |
| ISSN号 | 0366-6999 |
| 通讯作者 | Guo ji-hong(yxh9956@vip.sina.com) |
| 英文摘要 | The action potential of pacemaker cells in the sino-atrial node forms the automatic rhythm of the heart. the automatic depolarization in phase 4 is the basis of the automaticity in pacemaker cells. many currents are included in phase 4, such as calcium current,(1) ttx-sensitive sodium current,(2) sustained inward current (i-si),(3) decay of delayed rectifier potassium current,(4) etc. funny current (i-f) has long been recognized as important in this phase and is activated at hyperpolarized potentials during cell diastole and in turn activates other currents to form automatic depolarization.(5) it is controlled by voltage and camp, an intracellular messenger, so the auto no-mic nerve can modulate this current by increasing or decreasing intracellular camp since a gene family termed hyperpolarization-activated cyclic nucleotidegated cation channel (hcn) was discovered to encode this channel, there are few domestic articles concerning the electrophysiology of the different types of this channel.(6) the aim of this article is to describe the electrophysiological properties of human hcn2 and hcn4 channels expressed in hek293 cells. |
| WOS关键词 | SINOATRIAL NODE CELLS ; PACEMAKER CHANNELS ; CURRENTS ; DEPOLARIZATION ; POTENTIALS ; LINKER |
| WOS研究方向 | General & Internal Medicine |
| WOS类目 | Medicine, General & Internal |
| 语种 | 英语 |
| WOS记录号 | WOS:000251298400019 |
| 出版者 | CHINESE MEDICAL ASSOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380038 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Guo Ji-hong |
| 作者单位 | 1.Beijing Univ Peoples Hosp, Dept Internal Med, Div Cardiac Electrophysiol, Beijing 100044, Peoples R China 2.Peking Univ, Coll Life Sci, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li Chun,Guo Ji-hong,Li Ji-wen,et al. Electrophysiology of hyperpolarization-activated cyclic nucleotidegated cation channel 2 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 expressed in hek293 cells[J]. Chinese medical journal,2007,120(22):2039-2041. |
| APA | Li Chun.,Guo Ji-hong.,Li Ji-wen.,Liu Yuan-wei.,Hao Xue-mei.,...&Wang Shi-qiang.(2007).Electrophysiology of hyperpolarization-activated cyclic nucleotidegated cation channel 2 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 expressed in hek293 cells.Chinese medical journal,120(22),2039-2041. |
| MLA | Li Chun,et al."Electrophysiology of hyperpolarization-activated cyclic nucleotidegated cation channel 2 and hyperpolarization-activated cyclic nucleotide-gated cation channel 4 expressed in hek293 cells".Chinese medical journal 120.22(2007):2039-2041. |
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来源：中国科学院大学
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