Preparation and properties of thermo-sensitive hydrogels of konjac glucomannan grafted n-isopropylacrylamide for controlled drug delivery
文献类型：期刊论文
| 作者 | Zuo Chun Xiong; He Chun Chen; Xiao Chuan Huang; Li Ang Xu; Li Fang Zhang; Cheng Dong Xiong |
| 刊名 | Iranian polymer journal
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 16期号:6页码:425-431 |
| ISSN号 | 1026-1265 |
| 关键词 | Thermo-sensitive N-isopropylacrylamide Drug delivery Konjac glucomannan Hydrogels |
| 通讯作者 | Cheng dong xiong(xiongcd@yahoo.com.cn) |
| 英文摘要 | A thermo-sensitive hydrogel designed for controlled drug delivery was prepared and its properties were studied. the hydrogel was made of konjac glucomannan (kgm), copolymerized with n-isopropylacrylamide (nipaam) and crosslinked by n,n-methylene-bis-(acrylamide) (bis). several key parameters influencing the equilibrium swelling ratios of the hydrogels were studied. the swelling ratio was mainly controlled by the content of bis, and influenced by the ratio of nipaam/kgm, slightly. it was possible to control the degree of swelling of the gels by changing crosslinking density of the polymer. the gels swelling ratio has possessed sensitive response to the environmental temperature. in vitro release of model drug bovine serum albumin (bsa) was studied at 20 degrees c and 37 degrees c in phosphate buffer solution (pbs) of ph 7.4. the accumulative release percentages are nearly 80% and 30% after 5 h at 20 degrees c and 37 degrees c, respectively. |
| WOS关键词 | ACRYLIC-ACID ; CHITOSAN ; GUM |
| WOS研究方向 | Polymer Science |
| WOS类目 | Polymer Science |
| 语种 | 英语 |
| 出版者 | POLYMER RESEARCH CENTER IRAN |
| WOS记录号 | WOS:000249680600007 |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380094 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Cheng Dong Xiong |
| 作者单位 | 1.Chinese Acad Sci, Inst Organ Chem, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China 3.Sichuan Univ, Chengdu 610065, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zuo Chun Xiong,He Chun Chen,Xiao Chuan Huang,et al. Preparation and properties of thermo-sensitive hydrogels of konjac glucomannan grafted n-isopropylacrylamide for controlled drug delivery[J]. Iranian polymer journal,2007,16(6):425-431. |
| APA | Zuo Chun Xiong,He Chun Chen,Xiao Chuan Huang,Li Ang Xu,Li Fang Zhang,&Cheng Dong Xiong.(2007).Preparation and properties of thermo-sensitive hydrogels of konjac glucomannan grafted n-isopropylacrylamide for controlled drug delivery.Iranian polymer journal,16(6),425-431. |
| MLA | Zuo Chun Xiong,et al."Preparation and properties of thermo-sensitive hydrogels of konjac glucomannan grafted n-isopropylacrylamide for controlled drug delivery".Iranian polymer journal 16.6(2007):425-431. |
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来源：中国科学院大学
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