Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents
文献类型：期刊论文
| 作者 | Shi, Chang Qing; Liu, Zhang Qin; Lin, Wen Qing; Chen, Yuan Wei |
| 刊名 | Chinese chemical letters
 |
| 出版日期 | 2007-08-01 |
| 卷号 | 18期号:8页码:899-901 |
| 关键词 | Indoles Synthesis Kinesin spindle protein inhibitor Cytotoxicity Cancer treatment |
| ISSN号 | 1001-8417 |
| DOI | 10.1016/j.cclet.2007.05.052 |
| 通讯作者 | Chen, yuan wei(chenyw@cioc.ac.en) |
| 英文摘要 | A variety of indole derivatives were designed, synthesized and preliminarily evaluated for their in vitro cytotoxic activity in the a431 and h460 cell lines. all the compounds examined conferred unusual potency in a tumor cell cytotoxicity assay. the findings showed the indole derivatives would be a promising candidate for the development of new anticancer agents. (c) 2007 yuan wei chen. published by elsevier b.v. on behalf of chinese chemical society. all rights reserved. |
| WOS关键词 | SPINDLE PROTEIN KSP ; MITOTIC KINESIN EG5 ; INHIBITORS ; DISCOVERY ; MOTORS |
| WOS研究方向 | Chemistry |
| WOS类目 | Chemistry, Multidisciplinary |
| 语种 | 英语 |
| WOS记录号 | WOS:000248994600002 |
| 出版者 | CHINESE CHEMICAL SOC |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380102 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Chen, Yuan Wei |
| 作者单位 | 1.Chinese Acad Sci, Chengdu Inst Organ Chem, Key Lab Asymmetr Synth & Chirotechnol Sichuan Pro, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Chengdu Inst Organ Chem, Union Lab Asymmetr Synth, Chengdu 610041, Peoples R China 3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shi, Chang Qing,Liu, Zhang Qin,Lin, Wen Qing,et al. Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents[J]. Chinese chemical letters,2007,18(8):899-901. |
| APA | Shi, Chang Qing,Liu, Zhang Qin,Lin, Wen Qing,&Chen, Yuan Wei.(2007).Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents.Chinese chemical letters,18(8),899-901. |
| MLA | Shi, Chang Qing,et al."Synthesis and preliminary cytotoxic evaluation of substituted indoles as potential anticancer agents".Chinese chemical letters 18.8(2007):899-901. |
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来源：中国科学院大学
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