Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation
文献类型：期刊论文
| 作者 | Li, Wei2; Liu, Yong1; Zhang, Jiang-Wei1; Ai, Chun-Zhi2; Xiang, Nan3; Liu, Hui-Xin2; Yang, Ling1 |
| 刊名 | archives of pharmacal research
 |
| 出版日期 | 2009 |
| 卷号 | 32期号:1页码:49-57 |
| 关键词 | Ginsenosides Structure-activity relationship Anti-androgen-independent prostate cancer In vitro Intestinal bacterial metabolites |
| 产权排序 | 1;1 |
| 通讯作者 | 杨凌 |
| 英文摘要 | treatment of androgen-independent prostate cancer (aipc) remains unsatisfactory. in our present experiment, natural occurring ginsenosides (nogs) and intestinal bacterial metabolites (ibms) were employed to investigate their anti-aipc cell growth activity using pc-3 cells. our results showed that the ibms exerted more portent anti-aipc activity than nogs, by decreasing survival rate, inhibiting proliferation, inducing apoptosis, and leading to cell cycle arrest in aipc pc-3 cells. the increase of logp and decrease of c-6 steric hindrance, which were caused by deglycosylation by intestinal bacteria, may be the reason for the higher anti-aipc activity of ibms. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | chemistry, medicinal ; pharmacology & pharmacy |
| 研究领域[WOS] | pharmacology & pharmacy |
| 关键词[WOS] | intestinal bacterial metabolite ; human cytochrome-p450 enzymes ; plant glycosides ; panax-ginseng ; cell-line ; apoptosis ; proliferation ; mitochondria ; activation ; saponins |
| 收录类别 | SCI |
| 原文出处 | false |
| 语种 | 英语 |
| WOS记录号 | WOS:000262851700007 |
| 公开日期 | 2010-11-30 |
| 源URL | [http://159.226.238.44/handle/321008/101529]  |
| 专题 | 大连化学物理研究所_中国科学院大连化学物理研究所 |
| 作者单位 | 1.Chinese Acad Sci, Dalian Inst Chem Phys, Lab Pharmaceut Resource Discovery, Dalian 116023, Peoples R China 2.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China 3.Dalian Med Univ, Dalian 116027, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Wei,Liu, Yong,Zhang, Jiang-Wei,et al. Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation[J]. archives of pharmacal research,2009,32(1):49-57. |
| APA | Li, Wei.,Liu, Yong.,Zhang, Jiang-Wei.,Ai, Chun-Zhi.,Xiang, Nan.,...&Yang, Ling.(2009).Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation.archives of pharmacal research,32(1),49-57. |
| MLA | Li, Wei,et al."Anti-androgen-independent prostate cancer effects of ginsenoside metabolites In Vitro: Mechanism and possible structure-activity relationship investigation".archives of pharmacal research 32.1(2009):49-57. |
入库方式： OAI收割
来源：大连化学物理研究所
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