Electrospray tandem mass spectrometry of epipolythiodioxopiperazines
文献类型：期刊论文
| 作者 | Wu, Zhi-Jun; Li, Guo-You; Fang, Dong-Mei; Qi, Hua-Yi; Ren, Wei-Jian; Zhang, Guo-Lin |
| 刊名 | Journal of mass spectrometry
 |
| 出版日期 | 2007-06-01 |
| 卷号 | 42期号:6页码:749-760 |
| 关键词 | Electrospray ionization Epipolythiodioxopiperazine Chaetomium cochliodes Mclafferty rearrangement Heptacyclic rearrangement Fragmentation mechanism |
| ISSN号 | 1076-5174 |
| DOI | 10.1002/jms.1209 |
| 通讯作者 | Zhang, guo-lin(zhanggl@cib.ac.cn) |
| 英文摘要 | Low-energy collision-induced electrospray ionization tandem mass spectrometry esi-cid-ms/ms (in the positive ion mode) was used for the structural characterization of a series of five representative epioplythiodioxopipreazines: dethiotetra(methylthio)chemotin, chaetocochins a, b and c, and chernotin isolated from the fungus chaetomium cochliodes. the fragmentation pathways were elucidated by esi-it-msn. the elemental compositions of most of the product ions were confirmed by low-energy esi-cid-qtof-ms/ms analyses. the loss of the s-2 molecule seems always to be the first when the s-s bond is present. the loss of 77 da corresponding to the loss of the [ch3sch2o]' radical was diagnostic for chaetocochins a and b, in which the two piperazines rings are linked by an acetal group. it was found that a mclafferty rearrangement plays a significant role in the skeleton fragmentation of theses series of studied complex multicyclic piperazine compounds. this maclafferty rearrangement affords the product ions at m/z 416 and 400, containing the two piperazine rings belonging to the epipolythiodioxopipreazines. in addition, the pentacyclic rearrangement involving the loss of the sme center dot radical seems to occur in the presence of the unfused ring. finally the product ions at m/z 635 and 591 seem to be the characteristic ions for chaetocochin a. copyright (c) 2007 john wiley & sons, ltd. |
| WOS关键词 | KINZE EX FR ; CHAETOMIUM-COCHLIODES ; GLIOCLADIUM-ROSEUM ; METABOLITES ; CHETOMIN |
| WOS研究方向 | Biophysics ; Chemistry ; Spectroscopy |
| WOS类目 | Biophysics ; Chemistry, Organic ; Spectroscopy |
| 语种 | 英语 |
| WOS记录号 | WOS:000247421000005 |
| 出版者 | JOHN WILEY & SONS LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380207 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Zhang, Guo-Lin |
| 作者单位 | 1.Chinese Acad Sci, Inst Biol, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Zhi-Jun,Li, Guo-You,Fang, Dong-Mei,et al. Electrospray tandem mass spectrometry of epipolythiodioxopiperazines[J]. Journal of mass spectrometry,2007,42(6):749-760. |
| APA | Wu, Zhi-Jun,Li, Guo-You,Fang, Dong-Mei,Qi, Hua-Yi,Ren, Wei-Jian,&Zhang, Guo-Lin.(2007).Electrospray tandem mass spectrometry of epipolythiodioxopiperazines.Journal of mass spectrometry,42(6),749-760. |
| MLA | Wu, Zhi-Jun,et al."Electrospray tandem mass spectrometry of epipolythiodioxopiperazines".Journal of mass spectrometry 42.6(2007):749-760. |
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来源：中国科学院大学
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