Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation
文献类型：期刊论文
| 作者 | Zhao, Yanhong; Wang, Bin; Gao, Yuan; Zhao, Yannan; Xiao, Zhifeng; Zhao, Wenxue; Chen, Bing; Wang, Xia; Dai, Jianwu |
| 刊名 | Neuroscience letters
 |
| 出版日期 | 2007-06-29 |
| 卷号 | 421期号:3页码:197-202 |
| 关键词 | Oecs Apoptosis Caspase Mitochondria P53 Ischemia |
| ISSN号 | 0304-3940 |
| DOI | 10.1016/j.neulet.2007.04.028 |
| 通讯作者 | Dai, jianwu(jwdai@genetics.ac.cn) |
| 英文摘要 | Olfactory ensheathing cell (oec) transplantation is one promising technology for the treatment of spinal cord injury. many studies have been focusing on the functional improvement after oec implantation in spinal cord injury of animals. however, little is known about the mechanisms about how oecs respond to the proapoptotic microenviromnent after transplantation. we use the hypoxia and serum deprivation (hsd) paradigm in oecs to evaluate the effects of the ischemic damage. oecs underwent caspase-dependent apoptosis during hsd and a pan-caspase inhibitor specifically blocked the cell death. in addition, hsd resulted in a time-dependent decrease. of mitochondrial membrane potential delta psi(m) triggering a transient increase in p53 content and activated p53 in a time-dependent manner. in summary, our data suggest that hsd trigger apoptotic oecs death. which may be related to mitochondria dysfunction and the dependence of p53. (c) 2007 elsevier ireland ltd. all rights reserved. |
| WOS关键词 | SPINAL-CORD-INJURY ; FUNCTIONAL RECOVERY ; CYTOCHROME-C ; P53 PROTEIN ; GLIA ; DEATH ; REGENERATION ; RATS ; MITOCHONDRIA ; EXPRESSION |
| WOS研究方向 | Neurosciences & Neurology |
| WOS类目 | Neurosciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000248152100003 |
| 出版者 | ELSEVIER IRELAND LTD |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380210 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Dai, Jianwu |
| 作者单位 | 1.Chinese Acad Sci, Inst Genet & Dev Biol, Key Lab Mol Dev Biol, Beijing 100080, Peoples R China 2.Chinese Acad Sci, Grad Sch, Beijing 100080, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yanhong,Wang, Bin,Gao, Yuan,et al. Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation[J]. Neuroscience letters,2007,421(3):197-202. |
| APA | Zhao, Yanhong.,Wang, Bin.,Gao, Yuan.,Zhao, Yannan.,Xiao, Zhifeng.,...&Dai, Jianwu.(2007).Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation.Neuroscience letters,421(3),197-202. |
| MLA | Zhao, Yanhong,et al."Olfactory ensheathing cell apoptosis induced by hypoxia and serum deprivation".Neuroscience letters 421.3(2007):197-202. |
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来源：中国科学院大学
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