Rat epileptic seizures evoked by bmk alpha iv and its possible mechanisms involved in sodium channels
文献类型：期刊论文
| 作者 | Chai, Zhi-Fang; Bai, Zhan-Tao; Zhang, Xu-Ying; Liu, Tong; Pang, Xue-Yan; Ji, Yong-Hua |
| 刊名 | Toxicology and applied pharmacology
 |
| 出版日期 | 2007-05-01 |
| 卷号 | 220期号:3页码:235-242 |
| 关键词 | Bmk alpha iv Epileptic seizure Cerebrocortical synaptosomes Glutamate release Sodium channels Ion imaging |
| ISSN号 | 0041-008X |
| DOI | 10.1016/j.taap.2007.01.006 |
| 通讯作者 | Ji, yong-hua(yhji@server.shcnc.ac.cn) |
| 英文摘要 | This study showed that rat unilateral intracerebroventricular injection of bmk alpha iv, a sodium channel modulator derived from scorpion buthus martensi karsch, induced clusters of spikes, epileptic discharges and convulsion-related behavioral changes. bmk alpha iv potently promoted the release of endogenous glutamate from rat cerebrocortical synaptosomes. in vitro examination of the effect of bmk alpha iv on intrasynaptosomal free calcium concentration [ca2+](i) and sodium concentration [na+](i) revealed that bmk alpha-iv-evoked glutamate release from synaptosomes was associated with an increase in ca2+ and na+ influx. moreover, bmk alpha iv-mediated glutamate release and ion influx was completely blocked by tetrodotoxin, a blocker of sodium channel. together, these results suggest that the induction of bmk alpha iv-evoked epileptic seizures may be involved in the modulation of bmk alpha iv on tetrodotoxin-sensitive sodium channels located on the nerve terminal, which subsequently enhances the ca2+ influx to cause an increase of glutamate release. these findings may provide some insight regarding the mechanism of neuronal action of bmk alpha iv in the central nervous system for understanding epileptogenesis involved in sodium channels. (c) 2007 elsevier inc. all rights reserved. |
| WOS关键词 | SERRULATUS SCORPION-VENOM ; BUTHUS-MARTENSI KARSCH ; GLUTAMATE RELEASE ; ANTIEPILEPTIC DRUGS ; FEBRILE SEIZURES ; INTRAHIPPOCAMPAL INJECTION ; CORTICAL SYNAPTOSOMES ; GENERALIZED EPILEPSY ; NA+ ; TOXIN |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| WOS类目 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000246325600002 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380221 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Ji, Yong-Hua |
| 作者单位 | 1.Shanghai Univ, Sch Life Sci, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Physiol, Inst Biol Sci, Grad Sch, Shanghai 200031, Peoples R China 3.NIEHS, Membrane Signaling Grp, Lab Neurobiol, NIH, Res Triangle Pk, NC 27709 USA |
| 推荐引用方式 GB/T 7714 | Chai, Zhi-Fang,Bai, Zhan-Tao,Zhang, Xu-Ying,et al. Rat epileptic seizures evoked by bmk alpha iv and its possible mechanisms involved in sodium channels[J]. Toxicology and applied pharmacology,2007,220(3):235-242. |
| APA | Chai, Zhi-Fang,Bai, Zhan-Tao,Zhang, Xu-Ying,Liu, Tong,Pang, Xue-Yan,&Ji, Yong-Hua.(2007).Rat epileptic seizures evoked by bmk alpha iv and its possible mechanisms involved in sodium channels.Toxicology and applied pharmacology,220(3),235-242. |
| MLA | Chai, Zhi-Fang,et al."Rat epileptic seizures evoked by bmk alpha iv and its possible mechanisms involved in sodium channels".Toxicology and applied pharmacology 220.3(2007):235-242. |
入库方式： iSwitch采集
来源：中国科学院大学
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。