A glimpse of streptococcal toxic shock syndrome from comparative genomics of s-suis 2 chinese isolates
文献类型：期刊论文
| 作者 | Chen, Chen2,5; Tang, Jiaqi1; Dong, Wei2,5; Wang, Changjun1; Feng, Youjun4,8,9; Wang, Jing2,5; Zheng, Feng1; Pan, Xiuzhen1; Liu, Di4,8; Li, Ming1 |
| 刊名 | Plos one
 |
| 出版日期 | 2007-03-21 |
| 卷号 | 2期号:3页码:9 |
| ISSN号 | 1932-6203 |
| DOI | 10.1371/journal.pone.0000315 |
| 通讯作者 | Tang, jiaqi(tjq85@hotmail.com) |
| 英文摘要 | Background. streptococcus suis serotype 2 (ss2) is an important zoonotic pathogen, causing more than 200 cases of severe human infection worldwide, with the hallmarks of meningitis, septicemia, arthritis, etc. very recently, ss2 has been recognized as an etiological agent for streptococcal toxic shock syndrome (stss), which was originally associated with streptococcus pyogenes (gas) in streptococci. however, the molecular mechanisms underlying stss are poorly understood. methods and findings. to elucidate the genetic determinants of stss caused by ss2, whole genome sequencing of 3 different chinese ss2 strains was undertaken. comparative genomics accompanied by several lines of experiments, including experimental animal infection, pcr assay, and expression analysis, were utilized to further dissect a candidate pathogenicity island (pai). here we show, for the first time, a novel molecular insight into chinese isolates of highly invasive ss2, which caused two large-scale human stss outbreaks in china. a candidate pai of similar to 89 kb in length, which is designated 89k and specific for chinese ss2 virulent isolates, was investigated at the genomic level. it shares the universal properties of pais such as distinct gc content, consistent with its pivotal role in stss and high virulence. conclusions. to our knowledge, this is the first pai candidate from s. suis worldwide. our finding thus sheds light on stss triggered by ss2 at the genomic level, facilitates further understanding of its pathogenesis and points to directions of development on some effective strategies to combat highly pathogenic ss2 infections. |
| WOS研究方向 | Science & Technology - Other Topics |
| WOS类目 | Multidisciplinary Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000207445100017 |
| 出版者 | PUBLIC LIBRARY SCIENCE |
| URI标识 | http://www.irgrid.ac.cn/handle/1471x/2380223 |
| 专题 | 中国科学院大学 |
| 通讯作者 | Tang, Jiaqi |
| 作者单位 | 1.Res Inst Med Nanjing Command, Dept Epidemiol, Nanjing, Peoples R China 2.Chinese Acad Sci, Beijing Genom Inst, Beijing, Peoples R China 3.Acad Mil Med Sci, Inst Microbiol & Epidemiol, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, Ctr Mol Immunol, Beijing, Peoples R China 5.Zhejiang Univ, James D Watson Inst Genome Sci, Hangzhou 310003, Zhejiang, Peoples R China 6.S China Univ Technol, Sch Biosci & Bioengn, Guangzhou, Guangdong, Peoples R China 7.Univ Aarhus, Inst Human Genet, Aarhus, Denmark 8.Chinese Acad Sci, Inst Microbiol, China Japan Joint Lab Mol Immunol & Mol Microbiol, Beijing, Peoples R China 9.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Chen,Tang, Jiaqi,Dong, Wei,et al. A glimpse of streptococcal toxic shock syndrome from comparative genomics of s-suis 2 chinese isolates[J]. Plos one,2007,2(3):9. |
| APA | Chen, Chen.,Tang, Jiaqi.,Dong, Wei.,Wang, Changjun.,Feng, Youjun.,...&Yu, Jun.(2007).A glimpse of streptococcal toxic shock syndrome from comparative genomics of s-suis 2 chinese isolates.Plos one,2(3),9. |
| MLA | Chen, Chen,et al."A glimpse of streptococcal toxic shock syndrome from comparative genomics of s-suis 2 chinese isolates".Plos one 2.3(2007):9. |
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来源：中国科学院大学
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